中文摘要：

从宾川乌头（Aconitum duclouxii Levl.）的块根中分离得到了4个二萜生物碱，采用现代波谱技术，包括高分辨质谱、单晶X衍射、一维和二维核磁共振，将上述化合物分别鉴定为：ducloudineA（宾乌定甲）（1），ducloudineB（宾乌定乙）（2），14-O-乙酰尼奥宁（3）和乌头碱（4）．其中化合物1和2为新化合物，化合物3为首次从该植物中分离得到．化合物1和2的抗肿瘤细胞活性实验表明，其对5种肿瘤细胞（HL-60，A549，SMMC-7721，MCF-7，SW480）均没有体外生长抑制活性（IC50〉40μmol／L）．

英文摘要：

Two new C-19-diterpenoid alkaloids, ducloudines A （1） and B （2）, together with two known alkaloids of 14-acetylneoline （3） and aconitine （4）, were isolated from the roots ofAconitum duclouxii Levi. The structures of new alka- loids were established on the basis of spectral data （HR-MS, X-ray crystallographic analysis, 1D- and 2D-NMR）. Cytotoxicities of compounds 1 and 2 were tested against five cancer cell lines （HL-60, A549, SMMC-7721, MCF-7, SW480）. Results showed that compounds 1 and 2 had no cytotoxic effects on these five tumor cells （IC50〉40 μmol/L）.