中文摘要：

目的：探讨重度子痫前期（s-PE）伴发代谢综合征（MS）的临床特点。方法：2006年12月至2012年4月江苏省人民医院妇幼分院共收治s-PE患者246例,其中伴MS者80例（代谢组）,未伴MS者166例（对照组）。比较两组患者的孕期体重指数（BMI）,发病孕周、终止妊娠孕周、临床体征、生化指标、并发症及母婴结局。结果：代谢组患者的BMI、水肿、胸水、腹水、脂肪肝发生率、血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、乳酸脱氢酶（LDH）、尿酸（UA）、24h尿蛋白定量、肌酐（Cr）、总胆固醇（TC）、三酰甘油（TG）、空腹血糖（FBG）水平、早产及新生儿窒息发生率均显著高于对照组（P〈0.05）;而血清高密度脂蛋白（HDL）显著低于对照组（P〈0.05）。结论：s-PE伴发MS者脂肪肝发生率较高,糖脂代谢异常较重,易发生肝肾功能损伤,且早产及新生儿窒息发生率高。

英文摘要：

Objective：To investigate the clinical characteristic of severe preeclampsia complicated with metabolic syndrome（MS）.Methods：246 cases（80 cases with metabolic syndrome as MS group and 166 cases without metabolic syndrome as control group） were retrospectively studied,which collected at Jiangsu Province Hospital from Dec.2006 to Apr.2012.Body mass index（BMI）,occurrence weeks and termination weeks,clinical characteristic,biochemical indicators,complications,and maternal-fetal outcome were analyzed respectively.Results：BMI,edema,pleural effusion,ascites,fatty liver,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,lctate dehydrogenase（LDH）,Uric acid（UA）,24h urinary protein,creatinine（Cr）,total cholesterol（TC）,triglyceride（TG）,fasting blood glucose（FBG）,Preterm birth and neonatal asphyxia rates in MS group were higher than that in the control group（P＆lt;0.05）.Serum high-density lipoprotein（HDL） was lower in MS group than that in the control group（P＆lt;0.05）.Conclusion：Pregnant wowen with severe preeclampsia complicated with metabolic syndrome has higher incidence of fatty liver,abnormal glucose and lipid metabolism more seriously.It is easier to suffer from anasarca,pleural effusion,ascites,liver and kidney injury.The incidences of preterm birth and neonatal asphyxia are higher.