中文摘要：

病理学的简历矿化作用能被象 preeclampsia 那样的疾病导致。由这些自然地发生的简历矿化作用进程启发了，我们设计了进程叫的控制蛋白质的肽汇编双人脚踏车肽模板简历矿化作用。这种技术在目标蛋白质的活动提供 bio-context-associated 数据，并且在联系生物微型环境便于蛋白质功能的评估。它能为 biosensing 应用程序与高敏感提供有效信号扩大是简历模仿的进程导致 Ag 装饰 nanoparticle 的肽 nanowires 的形成。因而，高温度的要求因素 A1 (HtrA1 ) 能是在临床的浆液样品的 assayed 份量上为 preeclampsia 的诊断和疾病的改进处理提供信息。结果建议这个过程在临床的实践为使用有可观的潜力。

英文摘要：

Pathological bio-mineralization can be induced by diseases such as preeclampsia. Inspired by these naturally occurring bio-mineralization processes, we have designed a process called protein-controlled peptide assembly tandem peptide- templated bio-mineralization. The technique provides bio-context-associated data on the activity of target proteins, and facilitates the evaluation of protein function in the associated biological microenvironment. It is a bio-mimetic process that leads to the formation of Ag nanoparticle-decorated peptide nanowires, which can offer efficient signal amplification with high sensitivity for biosensing applications. Consequently, high-temperature requirement factor A1 （HtrA1） can be assayed quantitatively in clinical serum samples to offer information for the diagnosis of preeclampsia and the improved treatment of the disease. The results suggest that the process has considerable potential for use in clinical practice.