中文摘要：

目的 明确芪苈强心胶囊中的药效物质成分。方法 采用UPLC串联Q-TOF-MS/MS对芪苈强心胶囊有效部位中的二萜类生物碱类成分进行了研究，使用质谱分析软件中的目标化合物筛查法，通过保留时间、精确相对分子质量和二级质谱裂解碎片鉴定监测到的化学成分。结果 从芪苈强心胶囊中共鉴定了20个二萜类生物碱，其中双酯型生物碱6个，单酯型生物碱14个。结论 本方法可以简单快捷地鉴定中药复方中的目标成分，为芪苈强心胶囊成分的明确和质量控制提供参考。

英文摘要：

Objective To study the chemical constituents in Qili Qiangxin Capsule （QQC） and to clear its material basis for efficacy. Methods A rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry （UPLC/Q- TOF-MS/MS） method was established to identify the diterpenoid alkaloids in the active fraction of QQC. Using target compound screening method, the structures of monitored chemical constituents were identified by retention time, exact relative molecular mass, and cleavage fragments of MS/MS. Results Twenty diterpenoid alkaloids were identified using XIC Manager, including 6 diester-diterpenoid alkaloids and 14 monoester-diterpenoid alkaloids. Conclusion This method is simple and rapid for the identification of the constituents in QQC and the results are useful for the quality control of QQC.