中文摘要：

目的探讨葛根素对脑缺血再灌注损伤保护作用的机制。方法采用大鼠大脑中动脉栓塞模型（MCAO），观察葛根素对脑缺血再灌注脑组织水肿及神经细胞Na^＋-K^＋-ATPase、Ca^2＋-ATPase活性的影响。结果葛根素能明显降低MCAO大鼠脑含水量，提高Na^＋-K^＋-ATPase、Ca^2＋-ATPase活性。结论大鼠MCAO后脑组织水肿明显，ATPase活性降低；葛根素可以减轻此类损伤，对脑组织具有保护作用。

英文摘要：

Objective： To explore the protective mechanism of Puerarin on cerebral ischemia - reperfusion injury. Methods： The ischemia -reperfusion model rats was induced by means of middle cerebral artery occlusian（MCAO）, the brain edema and Na ^＋ - K^ ＋ - ATPase, Ca^2 ＋ATPase activity in neuron were measured to study the effect of Perarin against cerebral ischemia - reperfusion injury. Results： Puerarin can significant decrease the brain edema in rats induced by MCAO, and increase the activity of Na ^＋ K ^＋ - ATPase, Ca^2＋ - APTase. Conclusions： The brain edama is obviously increased and the activity of ATPase is obviously decreased after MCAO. Puerarin can alleviate the injuriy and has the neuro -protective effect against ischemia -reperfusion injury.