位置:成果数据库 > 期刊 > 期刊详情页
Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin
  • ISSN号:0253-2670
  • 期刊名称:《中草药》
  • 时间:0
  • 分类:Q946.8[生物学—植物学] TQ465.5[化学工程—制药化工]
  • 作者机构:Department of Pharmaceutical Botany, School of Pharmacy,Second Military Medical University, Shanghai 200433, China
  • 相关基金:supported by the National Natural Science Foundation of China (Grant Nos. 31300159; U1405215);‘‘Pujiang Talent’’ program (13PJ1411000); Shanghai Science and Technology Development Funds (14QB1402700);Program 15391900500 from Science and Technology Commission of Shanghai Municipality and Technology Committee and Seedling Cultivation Fund of Outstanding Master, Second Military Medical University
中文摘要:

Artemisinin,首要的抗疟药药的关键成分,每年有大需求。本国的植物,生产 artemisinin 的小数量,作为它的主要来源留下并且因此导致 artemisinin 的短供应。加强的努力被执行了提高 artemisinin 生产。然而,经由在 artemisinin 生合成分支小径的 overexpressing 或下面调整的基因,平淡的新陈代谢的工程策略不是很有效的是需要。腺的能分泌的毛状体, Artemisia annua L 的表面上的 artemisinin 生合成的地点。( A。annua ) ,是为增加 artemisinin 产量的新目标。一般来说,在 A 的腺的能分泌的毛状体的人口和形态学。annua (AaGSTs ) 断然经常与 artemisinin 内容被相关。AaGSTs 的改进理解将为增加导出植物的 artemisinin 使机会清楚些。在 A 的毛状体的这个评论文章愿望刷新分类。annua 并且关于 AaGSTs 和 artemisinin 提供最近的成就的概述。为了有 AaGSTs,与毛状体形态学被联系的因素和密度愿望的完整的理解,不得不进一步被调查,例如基因, microRNAs 和植物激素。这评论的目的到过(1 ) 更新在 AaGSTs 和 artemisinin 之间的关系的知识,并且(2 ) 建议新大街由利用潜在的 biofactories 增加 artemisinin 产量, AaGSTs。

英文摘要:

Artemisinin, the key ingredient of first-line antimalarial drugs, has large demand every year. The native plant, which produces small quantities of artemisi- nin, remains as its main source and thus results in a short supply of artemisinin. Intensified efforts have been carried out to elevate artemisinin production. However, the routine metabolic engineering strategy, via overexpressing or down-regulating genes in artemisinin biosynthesis branch pathways, was not very effective as desired. Glandular secretory trichomes, sites of artemisinin biosynthesis on the surface of Artemisia annua L. (A. annua), are the new target for increasing artemisinin yield. In general, the population and morphology of glandular secretory tri- chomes in A. annua (AaGSTs) are often positively corre- lated with artemisinin content. Improved understanding of AaGSTs will shed light on the opportunities for increasing plant-derived artemisinin. This review article will refresh classification of trichomes in A. annua and provide an overview of the recent achievements regarding AaGSTs and artemisinin. To have a full understanding of AaGSTs, factors that are associated with trichome morphology and density will have to be further investigated, such as genes, microRNAs and phytohormones. The purpose of this review was to (1) update the knowledge of the relation between AaGSTs and artemisinin, and (2) propose new avenues to increase artemisinin yield by harnessing the potential biofactories, AaGSTs.

同期刊论文项目
同项目期刊论文
期刊信息
  • 《中草药》
  • 北大核心期刊(2011版)
  • 主管单位:天津市科委
  • 主办单位:中国药学会 天津药物研究院
  • 主编:汤立达
  • 地址:天津市南开区鞍山西道308号
  • 邮编:300193
  • 邮箱:zcy@tiprpress.com
  • 电话:022-27474913 23006821
  • 国际标准刊号:ISSN:0253-2670
  • 国内统一刊号:ISSN:12-1108/R
  • 邮发代号:6-77
  • 获奖情况:
  • 国家期刊奖,国家“双奖”期刊,1992年获国家科委、中共中央宣传部、国家新闻出版...
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:90909