中文摘要：

目的：检测三组散发型白癜风患者治疗前后外周血CD4＋／CD8＋T细胞比值及CD4＋CD25＋调节性T细胞水平，评价三种治疗方案对散发型白癜风免疫功能的影响。方法：将76例患者随机分为三组：治疗①组：单用吡美莫司治疗；治疗②组：吡美莫司联合中药方剂治疗；治疗③组：吡美莫司联合白芍总苷治疗，用流式细胞仪对三组患者治疗前后外周血CD4＋／CD8＋T细胞比值及CD4＋CD25＋调节性T细胞水平进行检测。结果：与治疗前相比，治疗后三组散发型白癜风患者外周血中CD4＋／CD8＋T细胞比值和CD4＋CD25＋调节性T细胞水平均升高，差异均有统计学意义（P值均〈0．05）。吡美莫司联合白芍总苷组变化水平高于单用吡美莫司组，但低于联合中药方剂组，差异均有统计学意义（P〈0．05）。结论：三种方案均能不同程度的提高散发型白癜风患者外周血CD4＋／CD8＋T细胞比值及CD4＋CD25＋调节性T细胞水平。

英文摘要：

Objective： To detect the CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in peripheral blood of patients with sporadic vitiligo, and to investigate the effect on im- mune system by the three treatments. Methods：76 patients with sporadic vitiligo were randomly divided into three groups： patients in group 1 were treated by pimecrolimus, patients in group 2 were treated by pimecrolimus and Chinese proprietary, patients in group 3 were treated by pimecrolimus and TGP. The CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in patients of the three groups, before and after treatment, were detected by flow cytometry. Results ： In each group, the CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level increased af- ter treatment（P 〈0. 05 ）. The CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in group 3 was higher than that in the group 1 which treated by pimecrolimus, but lower than in group 2 （P 〈 0. 05 ）. The difference showed statistical significance. Conclusion： All three treat- ments could improve the level of CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in patients with sporadic vitiligo.