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L-异核苷掺入的二核苷酸的合成与抗HIV活性研究
  • ISSN号：1003-1057
  • 期刊名称：《中国药学：英文版》
  • 时间：0
  • 分类：R916[医药卫生—药学]
  • 作者机构：[1]北京大学医学部天然药物及仿生药物国家重点实验室,药学院药物化学系,北京100191
  • 相关基金：National Natural Science Foundation of China （Grant No. 20832008 and 21002004）
作者： 王萌[1], 邢磊[1], 陆世芳[1], 关注[1], 杨振军[1], 张礼和[1]
关键词： HIV整合酶, 二核苷酸, 合成, 抗-HIV, 结合模式, HIV integrase, Dinucleotides, Synthesis, Anti-HIV, Binding modes
中文摘要：

本论文利用亚磷酰胺一釜法合成了三个5＇-端L-构型异核苷掺入的非天然二核苷酸, 对它们与HIV整合酶的结合模式进行了模拟, 并对它们在假病毒体系中的抗HIV活性进行了评价。

英文摘要：

Three dinucleotides containing L-isonucleosides at 5＇-end were synthesized by an elegant phosphoramidite one-pot method. Their binding modes with HIV integrase were simulated and their anti-HIV activities in pseudotyped virus system were examined.

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期刊信息
  • 《中国药学：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:北京大学药学院
  • 主编：王夔
  • 地址：北京市学院路38号
  • 邮编：100083
  • 邮箱：zggy@mail.bjmu.edu.cn
  • 电话：010-82801713
  • 国际标准刊号：ISSN：1003-1057
  • 国内统一刊号：ISSN：11-2863/R
  • 邮发代号:
  • 获奖情况:
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  • 被引量:708