中文摘要：

配准技术在基于多图谱的分割方法中能有效地将医学图谱的先验知识融入分割过程,再结合以高效的标记融合算法,最终实现精确地自动分割.针对图谱配准的较大误差及其对标记融合的重要影响,本文建立了一种新的概率图模型框架并以此提出了基于多参数配准模型的分割算法,将此方法与高效的标记融合算法相结合,可以提高目标图像中特定组织区域的分割精度,更使其在少量图谱分割的情形下具有重要应用.首先,使用多种配准参数对所有目标图像进行配准;然后,分别采用不同的算法对配准图像进行灰度融合和标记融合,实现训练图像的重构过程;最后,利用高效的标记融合算法对重构后的图像进行融合得到最终精确的分割结果.实验结果表明该方法均优于本文其他分割算法,能够有效提升脑部组织分割精度.

英文摘要：

Registration technology can effectively integrate the prior knowledge of medical atlases into the segmentation process,and then combine with the efficient label fusion algorithm to obtain the segmentation results accurately and automatically. Aimed at the large error in registration of target image and its great influence on label fusion,a framework of probabilistic graphical model is established and the idea of multi-parameter registration model is proposed. Combined with an efficient algorithm on label fusion,this framework can improve the segmentation accuracy of specific tissue regions on target image,which has important application value in segmentation with a fewavailable atlases. After the multi-parameter registration and the reconstruction process of training sets on target images,the final segmentation results are obtained by an efficient fusion algorithm. According to the experiment which was conducted on the brain magnetic resonance image segmentation with different segmentation methods,the proposed framework can effectively improve the accuracy of segmentation.