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中文摘要：
铅是一种严重的环境毒和神经毒,低浓度的铅主要影响儿童的智力发育和学习记忆功能.本项目在临床上研究了儿童多动症与血铅含量的相关性；研究了铅对海马神经元突触可塑性、通道、受体的损伤与药物修复机制；研究了铅对海马神经元发育关键期细胞分裂周期蛋白相关激酶 CDKs 的影响；以基因敲除动物为模型，研究铅影响神经系统学习记忆功能信号转导通路的基因调控机理；应用量子点标记技术结合激光共聚焦扫描显微镜技术能连续动态地观察标记的活细胞样品的特性，研究铅引起细胞形态学改变和细胞内大分子的作用位点,建立量子点标记技术在神经毒理学中的应用技术平台，同时研究了量子点的神经毒性和作用机制.通过这些研究,进一步阐明了铅对神经系统学习记忆功能的损伤与修复机理。
结论摘要：
英文主题词Evironmental lead expore; functions of learning and memory; CDKs;quantum dots labeling technique and toxicity
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期刊论文
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Opposite effects of alpha-lipoic acid on antioxidation and long-term potentiation in control and chr
Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated ra
Enriched environment restores impaired hippocampal long-term potentiation and water maze performance
Unmodified CdSe Quantum Dots Induced Elevation of Cytoplasmic Calcium Levels and Impairment of Funct
Case-control study of blood lead levels and attention deficit hyperactivity disorder in Chinese chil
Monosialoanglioside (GM1) prevents lead-induced neurotoxicity on long-term potentiation, SOD activit
Muscarinic cholinergic modulation of synaptic transmission and plasticity in rat hippocampus followi
Epigallocatechin-3-gallate induced primary cultures of rat hippocampal neurons death linked to calci
Effects of Decabrominated Diphenyl Ether (PBDE 209) Exposure at Different Developmental Periods on S
The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice h
Mercury-selenium association in antarctic seal hairs and animal excrements over the past 1,500 years
Clioquinol and vitamin B12 (cobalamin) synergistically rescue the lead-induced impairments of synapt
JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term sy
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