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中文摘要：
电子转移、疏水亲脂作用、一氧化氮转移及自由基诱导的过氧化反应等在生命过程中起着重要的作用。本项目用物理有机化学和自由基化学的理论和方法在模拟生物体系中对这些与生命过程有关的化学过程进行了深入的研究,为阐明它们生理作用的化学本质提供了基础理论数据。在以下诸方面取得突出的成果:（1）辅酶NADH 还原反应机理及生物活性分子的电子转移反应;（2）疏水亲脂作用引起的有机分子的簇集、解簇集和自卷及自由基自旋离域参数σ.JJ 的应用;（3）超分子体系中的光诱导电子转移、能量传递和化学转换;（4）一氧化氮自由基的电子转移和自由基转移;(5)生物抗氧化剂作用的协同效应和微环境效应。
结论摘要：
英文主题词Physical organic chemistry; Free radicals; Bioactive molecules ,Bioactive molecules
成果综合统计
期刊论文
会议论文
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期刊论文
Effects of Resveratrol and Its Analogs
on Scavenging Hydroxyl Radicals:
Evaluation by EPR Spin Trapp
Dissociation Energies and Charge
Distribution of Co-NO Bond for
Nitrosyl-α,β,γ,δ-tetraphenylporphina
Photoinduced Electron Transfer in a
Supramolecular Species Building of
Mono-6-p-nitrobenzoyl-β-cyclo
Kinetic and Mechjanistic Studies on the
Inhibition of Free Radical-Initiated
Polymerization of Styre
Photocontrollable Ion Transport across
a Liquid Membrane by Anthracene
End-Labeled Oligo-Oxyethylene
Two-photon-pumped frequencyupconverted
lasing and optical power
limiting properties of vinylbenzothi
Protective Effects of Resveratrol and its
Analogues against Free Radical-
Induced Oxidative Hemolysi
Long-lived Photoinduced Charge
Separation in Carbazole-pyreneviologen
System Incorporated in
Langmui
Interlayer Energy Transfer from
Naphthalene to Anthracene
Chromophores Organized in
Langmuir-Blodget
Efficiency and Structure-Activity
Relationship of the Antioxidant Action
of Resveratrol and its Anal
Thermal and photoinduced reduction of
some benzyl bromides by a NAD(P)H
model: the effect of electro
Antioxidant Effects of Green Tea
Polyphenols on Free Radical Initiated
Peroxidation of Rat Liver Mic
Antioxidant Effects of Resveratrol and
its Analogues against the Free
Radical-Induced Peroxidation o
Effects of self-coiling of organic
molecules on intramolecular exciplex
formation and fluorescence q
Water-in-Oil Microemulsions as
Microreactors to Control the
Regioselectivity in the Photocycloadditi
A new type of deaggregators, the
bolaamphiphilic DeAgrs. Observations
of the dependence of deaggrega
Controlled Photocyclization, Photodimerizaiton
and Photoisomerization of
Stilbazole Salts within Naf
A comparative study on photosensitized
oxidation of trans-2-vinylthiophenes
with trans-3-vinylthioph
Nucleophilic Substitution Reaction of
p-Dinitrobenzene by a Carbanion:
Evidence for Electron Transfe
Novel photo-induced coupling reaction
of 9-fluorenylidenemalononitrile with
10-methyl-9,10-dihydroac
Self-assembling calix[4]arene
[2]catenanes. Preorganization,
conformation, selectivity, and
efficien
Effect of coaggregate formation on the
fluorescence quenching of anthracene
derivatives by m-N,N-die
19F NMR study on the charge-transfer
process between ground state acceptor
fluoranil (or pentafluoro
Antioxidant Effect of Coumarin
Derivatives on Free Radical Initiated
and Photosensitized Peroxidatio
A High-yielding and Facile Preparation
of N-Substituted Thioureas by
Substitution of Nitrosothiourea
Is NO (Nitric Oxide) an Electron
Acceptor or an Electrophile ? A
Detailed Thermodynamic Investigatio
Kinetic studies on the single electron
transfer reaction between 2,2,6,6-
tetramethylpiperidine oxoa
Enhancement of Intramolecular
Photocycloaddition of Bichromophoric
Compounds via Inclusion in
Low-De
Electron Transfer between
N-Substituted Phenothiazines and the
1-Oxopiperidinium Ion in
the Presence
Which hydrogen atom is first
transferred in NAD(P)H model
Hantzsch ester (HEH) mediated
reactions vi
Dual-parameter correlation analysis of
the fluorescence data of
1-methyl-2-formyl-5- substituted
pyr
Antioxidative and Prooxidative Effects
of Coumarin Derivatives on Free
Radical Initiated and Photose
14N/15N and 12C/13C Equilibrium
Isotope Effects on the Electron-
Transfer Reaction between N-Methylp
Dual-parameter correlation analysis of
UV spectral data for 1-methyl-2-
formyl-5-Y-substituted pyrro
EPR studies of 1-methyl-2-substituted
5-pyrrolylcarbonyl fluorinated
nitroxided and dual-parameter
c
Aggregation of Novel Betaine
Surfactants
N-(3-Alkoxy-2-Hydroxypropyl)-N,
N-Dimethylglycines in Aqueo
A Theoretical Study on the Structure
and Properties of Phenothiazine
Derivatives and their Radical C
Long-Lived Photoinduced Charge-
Separation in Ru(bpy)3
2+/Viologen
System at Nafion Membrane-
Soluti
Reactions of N-methyl-N-nitrosotoluene-
p-sulfonamide (MNTS) with
3,6-Dibromocarbazole and Its
Corre
Interplay between Molecular
Recognition and Redox Properies: A
Theoretical Study of the Inclusion
Co
Heterolytic and Homolytic N-H Bond
Dissociation Energies of 4-Substituted
Hanzsch 2,6-Dimethyl-1,4-d
Hydrophobic acceleration of electrontransfer
fluorescence quenching
processes between excited 1-alka
Enhancement of Photoinduced
Intramolecular Cross-Cycloaddition of
α-(9-Anthryl)-w-(1-Naphthoyl)
End-
Enhencement of Photo-induced Charge
Sepatration in Cyclometallted
Platinum(II) Complex-Viologen
Syst
Applications of NAD(P)H Model
Hantzsch 1,4-Dihydropyridine as a
Mild Reducing Agent in Preparation o
Remarkable Product Selectivity in
Photocyclo-addition of Diaryl
Compounds and in Photosensitized
Oxi
Supramolecular complexation behavior
of novel cyclotriveratrylene derivatives
with benzoate pendants
Rotaxanes for Molecular Devices,
Self-Assembly of Fluorine-Containing
[2]Catenanes Based on
Donor-Ac
On the Direction and Magnitude of
Radical Substituent Effect: The Role of
Polar Interaction on Therm
Aggregation and Self-Coiling of
Organic Molecules Driven by
Hydrophobic and Lipophilic
Interactions,
EPR study on the complex formed by
charge-transfer process between
ground-state acceptor
2,3-dicyano
Stable Free Radicals Generated during
the Oxidation of 4-Alkyl Hantzsch
1,4-Dihydropyridines with
Ni
Enhencement of Quantum Yield and
Lifetime of Photoinduced Charge-
Separation for Cyclometallated
Pla
Homolytic Cleavage Energies of R-H
bonds Centered on Carbon Atoms of
High Electronegativity: The Fir
Mechanisms of the Oxidations of
NAD(P)H Model Hantzsch 1,4-
Dihydropyridines by Nitric Oxide and
Its
Mechanism of Reduction of
1,1-Diphenyl-2,2-dinitroethylene by
1-Benzyl-1,4-dihydronicotinamide:
Tran
Synthesis of Diazacrown Ethers with
Chromophores and Their Photoinduced
Charge-Separation with Methy
NO Affinities of S-nitrosothiols: A
Direct Experimental and
Computational Investigation of RS-NO
Bon
Crystal Structures of the Deoxygenation
Products and the
Characteristics of the Reactions of
Phenyl(
An Improved and Efficient Preparation
of the Chiral NAD(P)H Models
(Ss)-1-Benzyl-3-(p-tolysulfinyl)-
Heterolytic and Homolytic N-NO Bond
Dissociation Energies of N-nitroso
Compounds and Their Radical A
Electron-transfer fluorescence
quenching processes in coaggregates
between excited N-alkylcarbozoles
Antioxidative Effects of Green Tea
Polyphenols on Free Radical Initiated
and Photosensitized Peroxid
Study of the aggregation of 1-alkanoylperylenes
in 1,4-dioxane-water binary
solvents-derivation of a
The First O-NO Bond Energy Scales in
Solution: Heterolytic and Homolytic
Cleavage Enthalpies of O-ni
Liquid Chromatographic Resolution of
Racemic 2-Phenyl-1,1-cyclopropane
dicarbonitrile and its Analog
An Old but Simple and Efficient
Method to Elucidate the Oxidation
Mechanism of NAD(P)H Model
1-Aryl-
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