欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
肿瘤靶向MRI/NIR多模态探针可以有效地兼顾MRI高空间分辨率以及NIR成像灵敏、快速等优势，在医学基础研究和肿瘤临床诊断中具有重要的应用价值。为解决MRI成像对比度差、近红外光学成像穿透能力低以及肿瘤识别缺乏特异性等核心问题，利用自组装技术发展肿瘤靶向性的MRI/NIR多模态探针是关键所在。本研究采用自组装技术，设计和合成具有良好生物相容性的MRI、NIR及肿瘤靶向基元，构建具有肿瘤靶向作用的MRI/NIR多模态探针，并发展新型粗粒化分子模型对自组装过程进行理论模拟，从分子层面上阐明各种自组装体的结构与提高自组装探针的磁共振和近红外荧光信号的关系，为构建自组装多模态探针基元以及建立多模态分子探针可控自组装新方法提供理论依据。同时以荷瘤动物为研究对象，采用MRI和NIR成像方法，对所合成的多模态探针进行成像评价，为多模态肿瘤非侵入可视化技术提供新的思路和技术手段。
结论摘要：
英文主题词magnetic resonance imaging；fluorescent imaging；nanocarrier；molecular self-assembly；Coarse-Grained Model
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Enhanced photoluminescence and characterization of multicolor carbon dots using plant soot as a carb
Ultrasmall Chitosan–Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Pho
A mitochondria-targeted fluorescent probe based on TPP-conjugated carbon dots for both one- and two-
Bridging the missing Linking between structure and dynamics of the RNA-dependent RNA polymerase from
Preparation of europium complex-conjugated carbon dots for ratiometric fluorescence detection of cop
An Anisotropic Coarse-Grained Model for Proteins Based on Gay-Berne and Electric Multipole Potential
Presence of photoluminescent carbon dots in Nescafe (R) original instant coffee: Applications to bio
An anisotropic coarse-grained model based on Gay-Berne and electric multipole potentials and its app
Highly fluorescent carbon dots for visible sensing of doxorubicin release based on efficient nanosur
A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-can
N-doped carbon dots derived from bovine serum albumin and formic acid with one- and two-photon fluor
相关项目
谭明乾的项目