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中文摘要：
综合运用计算机组合库设计、化学合成、电生理和膜片钳记录技术，根据钾离子通道的晶体结构以及其他不同亚型的三维结构和作用机理，拟运用靶向组合库设计方法，采用自制软件包LD1设计并合成钾离子通道阻滞剂化合物库，通过电生理测试确定这些化合物对不同钾通道亚型、以及其他离子通道的选择性，进一步验证计算机组合库设计和虚拟筛选方法，寻找新型高强度、高选择性钾离子通道阻滞剂，并针对其药理作用进行结构优化，以发现新型与钾离子通道相关的疾病的创新药物。
结论摘要：
英文主题词k channel,blocker, Electrophysiological Assay,voltage-clamp recording
成果综合统计
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期刊论文
One-pot Approach for C-C Bond Formation through Ru-amino Complex Catalyzed Tandem Aldol Reaction/Hyd
Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src ty
Highly Enantio- and Diastereoselective Mannich Reaction of a Chiral Nickel(II) Glycinate with &alpha
Silver and Gold-mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium Hexa
Gold(I)-Catalyzed Tandem Transformation: A Simple Approach for the Synthesis of Pyrrolo/Pyrido[2,1-a
Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1
Gold(I)-Catalyzed Cascade for Synthesis of Pyrrolo[1,2-a:2',1'-c]/Pyrido[2,1-c]pyrrolo[1,2-a]quinoxa
Silver-Catalyzed Intramolecular Cyclization of o-(1-Alkynyl)- ACHTUNGTRENUNGbenzamides: Efficient Sy
Discovering Potent Inhibitors Against the Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) of Hel
Ligand-free Iron/Copper Cocatalyzed N-Arylations of Aryl Halides with Amines under Microwave Irradia
Gold-Catalyzed One-Pot Cascade Construction of Highly Functionalized Pyrrolo[1,2-a]quinolin-1(2H)-on
Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism f
Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from Ortho-Halophenols and 2-
Highly Diastereoselective Conjugate Addition-Elimination of Chiral Ni(II) Glycinate with Activated A
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