欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
本项目以微流控芯片化学发光检测为研究平台，以单细胞分析为研究对象，利用纳米粒子催化化学发光提高微流控芯片化学发光检测的灵敏度，通过特殊的微流控芯片化学发光检测系统的构建，建立适合于单细胞分析的微流控芯片纳米粒子催化化学发光检测方法，并对单细胞内及生物体内一些生物活性物质、疾病标志物进行检测，及在单细胞水平上进行药物筛选。期望在生命科学和生物医学基础研究及疾病的早期诊断中发挥重要作用。纳米粒子催化化学发光具有很高的灵敏度，将其与微流控芯片化学发光检测相结合，可以使现有的微流控芯片化学发光检测的灵敏度得到大的提高，解决当前微流控芯片化学发光检测灵敏度不太高的难题，从而使其能在复杂基体的超痕量、单细胞分析中，得到广泛应用。本课题首次提出将纳米粒子应用于微流控芯片化学发光检测及对单细胞进行分析，对于拓宽纳米材料在分析化学中的应用，推动微流控芯片的高灵敏检测技术及单细胞分析领域的发展具有重要意义。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Microchip fluorescence-enhanced immunoaasay for simultaneous quantification of multiple tumor marker
Trace analysisof D-tyrosine in biological samples by microchip electrophoresis with laser induced fl
Rapid screening of monoamine oxidase B inhibitors in natural extracts by capi- llary electrophoresis
Noncompetitive immunoassay for carcin- oembryonic antigen in human serum by MCE for cancer diagnosis
CE method with partial filling techniques for screening of xanthine oxidase inhibitor in traditional
A gold nanoparticle-mediated enzyme bioreactor for inhibitor screening by capillary electrophoresis.
Competitive immunoassay of phenobar- bital by microchip electrophoresis with laser induced fluoresce
Immobilized capillary adenosine deami- nase microreactor for inhibitor screening in natural extracts
A microchip electrophoresis strategy with online labeling and chemilumines- cence detection for simu
Ultrasensitive endonuclease activity and inhibition detection using gold nanopar- ticle-enhanced flu
A nonenzymatic chemiluminescent reac- tion enabling chemiluminescence reso- nance energy transfer to
Intermolecular and intramolecular quenchers based quantum dot nanopro- bes for multiplexed detection
Determination of intracellular sulphydryl compounds by MCE with selective chemiluminescence detectio
Microchip electrophoresis with chemiluminescence detection for assaying ascorbic acid and amino acid
Quantification of taurine and amino acids in mice single fibrosarcoma cell by microchip electrophore
One-way multiplexed immunoassay strategy for simultaneous determination of multi-analytes by microch
A sensitive and rapid immunoassay for quantification of testosterone by microchip electrophoresis wi
相关项目
赵书林的项目