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中文摘要：
持久性有机污染物（POPs）已经成为我国环境与人体健康的重要因素。本项目拟围绕典型POPs环境过程对毒性效应的影响这一关键科学问题，选取二恶英、PCBs、PBDEs、PFOSs等为主要目标化合物，按照污染物界面过程-生物有效性-累积放大机理-代谢过程与产物-毒性机制的研究思路，系统研究典型POPs的跨介质环境转移过程与生物有效性；典型POPs通过食物链的生物传递过程及与生物大分子作用机制；研究典型POPs在生物体内的代谢过程、代谢产物、代谢机理以及代谢物毒性；从分子水平、细胞水平和整体水平上探索其毒性效应机制。项目的目标是1）在新POPs研究方面取得创新性成果，推动学科发展；2）在环境过程与毒理方面获得重要科学数据，为国家履行斯德哥尔摩公约服务；3）通过分工协作和国内外学术交流培养人才，形成高水平POPs研究群体。
英文摘要：
Persistent organic pollutants；Interface；Bioavailability；Accumulation and metabolism；Toxic effect
结论摘要：
项目围绕持久性有机污染物（POPs）研究的关键科学问题和国家需求，分别在典型POPs的分析方法、环境微界面行为、食物链传递机制、在生物体内代谢途径及其分子毒理学机理等方面开展了深入研究。（1）建立了不同基质样品中多种新型POPs的分析方法和同步辐射技术为基础的污染物微界面过程原位分析方法，将建立的方法应用于实际环境和生物样品的分析。（2）系统研究了短链氯化石蜡的赋存状态、迁移转化、累积与放大行为，为履行斯德哥尔摩公约提供了科学支撑。（3）通过新技术思路的创新，在我国环境发现了TBC等10余种新型化学污染物，开始了这一新的研究方向。（4）开展了新型污染物溴代阻燃剂、全氟化合物的单一及复合暴露的毒性效应研究，推进了模式鱼类发育早期在毒理学研究中的应用。
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期刊论文
Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebr
Occurrence and fate of volatile siloxanes in a municipal Wastewater Treatment Plant of Beijing, Chin
Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larva
Different photolysis kinetics and photooxidation reactivities of neutral and anionic hydroxylated po
Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcripti
Effects of adrenergic agonists on the extrahepatic expression of vitellogenin Ao1 in heart and brain
Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers on Human Thyroid Receptor-beta: In V
Polybrominated Diphenyl Ethers (PBDEs), Polychlorinated Biphenyles (PCBs), Hydroxylated and Methoxyl
Distribution of Perfluorooctane Sulfonate and Other Perfluorochemicals in the Ambient Environment ar
Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary
Cytotoxicity and apoptosis induction on RTG-2 cells of 2,2 ';,4,4 ';-tetrabromodiphenyl ether (BDE-4
Solid phase extraction with pyrenebutyric acid-bonded silica for analysis of polychlorinated bipheny
Effects of fluorotelomer alcohol 8/2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP sign
Separation of polybrominated diphenyl ethers in fish for compound-specific stable carbon isotope ana
Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity i
Solubilization properties of polycyclic aromatic hydrocarbons by saponin, a plant-derived biosurfact
Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Ze
Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio
C-60-DOM interactions and effects on C-60 apparent solubility: A molecular mechanics and density fun
Polychlorinated biphenyls and organochlorinated pesticides in birds from a contaminated region in So
In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expressi
Preparation of a chitosan-coated C-18-functionalized magnetite nanoparticle sorbent for extraction o
Quantum Chemical Investigation on the Mechanism and Kinetics of PBDE Photooxidation by center dot OH
Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp1
Modulation of dietary fat on the toxicological effects in thymus and spleen in BALB/c mice exposed t
Distribution of PAHs in pine (Pinus thunbergii) needles and soils correlates with their gas-particle
The Essential Role of Endogenous Ghrelin in Growth Hormone Expression during Zebrafish Adenohypophys
Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafis
Elongation Factor ELL (Eleven-Nineteen Lysine-rich Leukemia) Acts as a Transcription Factor for Dire
Input Fate and Soil-air Exchange of Polycyclic Aromatic Hydrocarbons in Banshan Industry Park, China
Principal component analysis of fluoride geochemistry of groundwater in Shanxi and Inner Mongolia, C
Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcoh
Distribution of PCBs and PBDEs in soils along the altitudinal gradients of Balang Mountain, the east
Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transpor
Effect of surfactant-induced cell surface modifications on electron transport system and catechol 1,
Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of
Humic acids decrease the photodegradation of the sunscreen UV filter 2-phenylbenzimidazole-5-sulfoni
Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiou
Enhanced effects by mixtures of three estrogenic compounds at environmentally relevant levels on dev
Summer-winter concentrations and gas-particle partitioning of short chain chlorinated paraffins in t
Simultaneous determination of five estrogens and four androgens in water samples by online solid-pha
Assessment of Estrogenic Effects of Perfluoroalkyl Acids by Monitoring Ligand-induced Conformation S
Distribution and Preliminary Exposure Assessment of Bisphenol AF (BPAF) in Various Environmental Mat
Comparison of arsenic geochemical evolution in the Datong Basin (Shanxi) and Hetao Basin (Inner Mong
In vitro toxicity of acid-functionalized single-walled carbon nanotubes: Effects on murine macrophag
Aquatic toxicity of nanosilver colloids to different trophic organisms: Contributions of particles a
Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2
Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenom
DDTs in rice frogs (Rana limnocharis) from an agricultural site, South China: Tissue distribution, b
Brominated flame retardants in three terrestrial passerine birds from South China: Geographical patt
Specific and Sensitive Fluorescence Anisotropy Sensing of Guanine-Quadruplex Structures via a Photoi
Characterization of TCHQ-induced genotoxicity and mutagenesis using the pSP189 shuttle vector in mam
Fast defluorination and removal of norfloxacin by alginate/Fe@Fe3O4 core/shell structured nanopartic
The air-water exchange of polychlorinated biphenyls and polybrominated diphenyl ethers at an urban l
Species- and tissue-specific accumulation of Dechlorane Plus in three terrestrial passerine bird spe
Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated qu
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