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中文摘要：
要研究的科学问题目前，尚无适当的方法解决广泛存在的肿瘤耐药性问题；耐药性逆转剂与肿瘤部位多药耐药基因蛋白相互作用机理尚不明确。MDR1基因介导的P-GP过度表达和乳腺癌相关基因介导的BCRP过度表达引起的药物外排是导致肿瘤多药耐药的关键因素。将耐药逆转剂与化疗药同时注射体内，由于药物分布不同，导致两者不易同时输送到肿瘤部位；目的构建新的抗耐药隐形脂质体并研究其对肿瘤耐药基因MDR1和BCRP耐药基因的调节机制。内容主要分三个部分抗耐药隐形脂质体的构建、该脂质体对肿瘤耐药基因的调节机制、动物体内药动学与药效学的研究。本研究已有两年的前期结果，SCI论文接受1篇，相关研究国内外发表论文10篇。本研究除申请人等的SCI接受论文1篇外，尚无其他文献报道。意义探究新的抗肿瘤多药耐药性的方法与机制，以期取得新的抗耐药策略，提高化疗效果。
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Pulmonary gemcitabine delivery for treating lung cancer: pharmacokinetics and acute lung injury aspe
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A Continued Study on the Stealth Liposomal Topotecan Plus Amlodipine: In Vitro and In Vivo Character
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