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中文摘要：
民族植物药具有多组分药理效应的特点，准确对其多种活性成分体内协同代谢动力学过程进行同时定量表征具有重要意义。由于民族植物药体内代谢过程十分复杂，目前尚缺乏对其体内多种活性成分同时直接定量分析的有效手段。基于最新研究发现在高维数据解析中三阶校正比二阶校正具有明显的维数优势，拟运用多种现代分析仪器联用技术对民族植物药活性成分体内代谢动态过程进行多维数阵（四维数阵以上）表征，探索和发展高阶校正方法进行数据解析，不仅能获得多组分协同作用的药动学参数，而且有助于揭示多组分药理效应中各组分在体内血液吸收、尿粪排泄、器官和组织中的协同分布变化和相互作用时-量和时-效规律，从而为民族植物药的配伍组方、施药酌量、新药开发提供科学依据。本项目以期为民族植物药多活性成分体内协同代谢动力学过程中的同时直接定量分析建立一种新的分析方法和提供全新的应用模式，同时也为丰富化学计量学多维校正理论提供一些理论依据。
结论摘要：
英文主题词Traditional Chinese minority herbs；Bioactive ingredients；Synergistic pharmacokinetics；Multi-way quantitative characterization；High-order calibration
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