位置：立项数据库 > 立项详情页
细胞钙信号研究
  • 项目名称：细胞钙信号研究
  • 项目类别：创新研究群体科学基金
  • 批准号：31221002
  • 申请代码：C050402
  • 项目来源：国家自然科学基金
  • 研究期限：2013-01-01-2015-12-31
  • 项目负责人：程和平
  • 负责人职称：教授
  • 依托单位：北京大学
  • 批准年度：2012
中文摘要：

本群体以细胞钙火花学说创始人之一程和平（单篇引用1,100次，总引用9,200多次）为学术带头人，周专、肖瑞平等为主要成员，在长期合作及共建北京大学分子医学研究所过程中自然形成，其前身为教育部“细胞钙离子信号学”创新团队，其中二人为国家千人计划专家，三人获杰出青年，一人获中科院“百人计划”，二人为长江学者。程和平、周专、肖瑞平在心肌和神经内分泌细胞的钙离子调控研究方面做出过重要贡献，享有国际声誉。钙离子是最广泛、最重要的细胞信使，其失调导致许多人类重大疾病的发生。本研究群体以心血管、神经内分泌系统为研究对象，集中研究钙信号调控的基本机制、钙信号和细胞分泌过程的调控以及钙信号对细胞收缩、迁移、分化和再生的调控，同时注重机理研究与疾病发病机理的结合，锐意发展新技术和新方法。目标在钙信号分子机制及生物医学功能研究方面取得原创性成果，建成可持续发展的国际知名细胞钙信号研究集体。

中文主题词： 钙离子；信号转导；细胞；；
结论摘要：

英文主题词calcium；Signal transduction；Cell；；

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 83
  • 0
  • 0
  • 0
  • 0
期刊论文
ROS regulation of microdomain Ca2+ signalling at the dyads.
Superoxide constitutes a major signal of mitochondrial superoxide flash.
Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor.
The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery
Real Time Endocytosis Imaging as Rapid Assay of Ligand-GPCR Binding in Single Cells.
Overnutrition Stimulates Intestinal Epithelium Proliferation Through b-Catenin Signaling in Obese Mi
Imaging ROS signaling in cells and animals.
Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylat
Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish.
Synergistic Triggering of Superoxide Flashes by Mitochondrial Ca2+ Uniport and Basal Reactive Oxygen
Imaging Ca2+ Nanosparks in Heart With a New Targeted Biosensor
beta-Adrenergic-stimulated L-type channel Ca2+ entry mediates hypoxic Ca2+ overload in intact heart
Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency.
Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish.
Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permu
Identification of PI3K regulatory subunit p55 gamma as a novel inhibitor of vascular smooth muscle c
Overnutrition stimulates intestinal epithelium proliferation through beta-catenin signaling in obese
Temporal components of synapse-synapse transmission in dorsal striatum brain slices
Anti-malarial Drug Artemisinin Depletes Erythrocytes by Activating Apoptosis Pathways in Zebrafish
Endothelial Gab1 deficiency aggravates splenomegaly in portal hypertension independent of angiogenes
Endothelial mechanosensors: the gatekeepers of vascular homeostasis and adaptation under mechanical
Docosahexaenoic acid attenuates hypoxic pulmonary vasoconstriction by activating the large conductan
Recent advances in heart regeneration
Biased beta2-adrenoceptor signalling: pathophysiology and drug discovery.
Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations
Superoxide constitutes a major signal of mitochondrial superoxide flash
Kissing and nanotunneling mediate intermitochondrial communication in the heart
Extracellular Caper se inhibits quantal size of catecholamine release in adrenal slice chromaffin ce
Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations.
Mitochondrial flashes: New insights into mitochondrial ROS signaling and beyond.
Subsarcolemmal mitochondrial flashes induced by hypochlorite stimulation in cardiac myocytes.
Advances in receptor conformation research: the quest for functionally selective conformations focus
Tyrosine 308 Is Necessary for Ligand-directed G(s) Protein-biased Signaling of beta(2)-Adrenoceptor
Identification of PI3K regulatory subunit p55？ as a novel inhibitor of vascular smooth muscle cell p
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synerg
Calcium influx activates local adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic
Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes
Micro-management of pluripotent stem cells
p55 gamma functional mimetic peptide N24 blocks vascular proliferative disorders
Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish
Evolutionary Interrogation of Human Biology in Well-Annotated Genomic Framework of Rhesus Macaque
RNA editome in rhesus macaque shaped by purifying selection.
Large noncoding RNAs are promising regulators in embryonic stem cells.
Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from An
Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish.
Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle
Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta c
Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin ce
Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by
Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism
Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury
Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for s
PEG-PLA nanoparticles facilitate siRNA knockdown in adult zebrafish heart
Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin
Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum
Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisom
Kissing and Nanotunneling: Inter-mitochondrial Communication in the Heart.
β-Adrenergic-stimulated l-type channel Ca2+ entry mediates hypoxic Ca2+ overload in intact heart.
Heritable gene targeting with gRNA/Cas9 in rats.
Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasi
Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo.
Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons.
在恒河猴基因组学框架下研究人类演化与调控
MG53是人类疾病的“双刃剑”
Large Noncoding RNAs Are Promising Regulators in Embryonic Stem Cells
β肾上腺素受体与心力衰竭
Porcine diazepam-binding inhibitor and bovine diazepam-binding inhibitor affect morphine antinociception via different receptors
Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells
Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese University
Nifedipine promotes the proliferation and migration of breast cancer cells
相关项目
炎症状态嗅区粘液钙离子浓度影响嗅觉的基础及临床研究
期刊论文 4 会议论文 4
微乳液滴模板法构筑高分子自组装有序多孔膜
期刊论文 4
急性心肌梗塞后室性心律失常和凝血酶受体的激活
期刊论文 6
温针干预兔软骨退变的信号转导机制研究
期刊论文 8
甲胎蛋白对RAR-beta功能的影响及其信息调控分子样作用的机制研究
期刊论文 16 会议论文 9 获奖 2
多胺氧化酶途径相关的过氧化氢参与乙烯调控气孔运动的信号转导机制
期刊论文 14 获奖 8 著作 2
微流控芯片上光刻法制备微阵列用于细胞信号转导的研究
期刊论文 30 会议论文 17
2型糖尿病胰岛早期纤维化形成机制及药物干预研究
期刊论文 2 著作 2
钾依赖钠钙交换蛋白6在衰老所致β细胞功能下降中的作用及其机制研究
期刊论文 10
程和平的项目
细胞生物学及发育生物学
生理学
期刊论文 1
中法心血管分子医学论坛
细胞钙信号研究
期刊论文 1
超高时空分辨微型化双光子在体显微成像系统
期刊论文 4
参加9th HOPE Meeting会议
　重大心脏疾病分子机理和干预策略的基础研究
期刊论文 23
　线粒体功能障碍致早期心衰机制及干预策略研究
期刊论文 7
细胞钙信号转导与调控机理研究
期刊论文 13 会议论文 1
线粒体超氧炫分子机制和功能研究
钙信号前沿国际研讨会