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中文摘要：
人胰淀素（human amylin, hA）错误折叠形成的胰岛淀粉样蛋白沉积具有损伤胰岛β细胞功能及诱导β细胞凋亡的作用。研究表明，抑制hA的聚集可有效减少β细胞的凋亡。因此，hA 已成为2 型糖尿病治疗的一个新靶点。我们的前期研究发现，螺旋藻的活性成分藻蓝蛋白能够有效抑制hA诱导的胰岛β细胞凋亡。在此基础上，本项目将研究含硒藻胆蛋白对hA诱导的胰岛细胞凋亡的拮抗作用及其分子机制；基于ThT荧光分析、AFM、MALDI-TOF/MS等技术，分析含硒藻胆蛋白与hA的相互作用机理；应用实时荧光定量PCR法和Western blot法考察含硒藻胆蛋白对hA激活的MAPK、p53信号通路、死亡受体和线粒体凋亡信号通路等的阻断作用；建立高表达hA的转基因细胞株和分离大鼠原代胰岛细胞，进一步检测含硒藻胆蛋白对胰岛β细胞的保护作用。本研究可为寻找和开发靶点清楚、机制明确的2型糖尿病治疗药物提供科学依据。
结论摘要：
英文主题词selenium-containing phycocyanin；heterocyclic selenium；diabetes mellitus；Islet amyloid polypeptide；cell apoptosis
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期刊论文
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