欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
结论摘要：
缺氧严重影响健康，是多种疾病发生发展的共同关键因素。我们研究了神经-内分泌-免疫与低氧损伤和适应的关系，我们的重要发现如下低氧对下丘脑-垂体-肾上腺皮质轴的调节作用及CRF肽家族在低氧诱导的神经-内分泌的核心调控；低氧激活CRFR1受体进而驱动CRF/CRFmRNA表达激活HPA轴；CRFR1和神经肽ET-1共存于PVN区；NE通过a1/2受体促进 CRF分泌；低氧及与束缚复合应激对垂体CRFR1/CRFR2两受体有不同效应；低氧激活下丘脑SS和垂体CRFR1/2亚型受体，导致GH/GHmRNA和生长发育抑制；低氧激活IGF/IGFmRNA对GH 产生负反馈调节；低氧并复合束缚与寒冷激活PRL/PRLmRNA表达；证明CRFR1型受体是低氧胰岛素分泌抑制的根源；低氧抑制细胞和体液免疫功能，激活神经元和胶质细胞分泌细胞因子IL-6/ET-1,水通道4可能参与严重低氧下的脑水肿形成；系统比较了高原动物和平原实验动物对低氧适应的分子机制，发现 IGF家族基因低氧的适应保护作用以及对低氧呈多模式应答,抗低氧基因转录"多元化"现象；提出妊娠期低氧对子代不同发育期HPA轴功能和行为学产生明显影响
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Neonatal exposure to intermittent hypoxia enhances mice performance in water maze and 8-arm radial m
Report on the 5th Comparative Physiology Conference of Chinese Association for Physiological Science
Intermittent hypoxia impairs performance of adult mice in the two-way shuttle box but not in the Mor
CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prola
Diversities in hepatic HIF-1, IGF-I/IGFBP-1, LDH/ICD, and their mRNA expressions induced by CoCl2 in
Corticotropin-Releasing Factor Receptor Type 1 and 2 mRNA Expression in the Rat Anterior Pituitary i
Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downreg
The effect of hypoxia on gill morphology and ionoregulatory status in the Lake Qinghai scaleless car
Diversity in a Changing Environment” - the International Conference of Comparative Physiology, Bioch
会议论文
Hippocampal SPAR expression is associated with intermittent hypoxia-induced enhancement of spatial l
NF-κB functions the diversity of cellular IGF-I/IGFBP-1 expression by hypoxia in Tibetan Plateau mam
Cloning and Evolution of HIF-1α cDNA from Tibetan vertebrates: Pantholops hodgsoni, Myospalax bailey
Expressions of CoCl2-induced immunoreactive hypoxia-inducible factor-1alpha, insulin-like growth fac
Molecular cloning and evolutionary analysis of hypoxia-inducible factor 1 alpha, and EPO responsiven
CRFR1 mediates hypoxia-induced cerebral edema through stimulating brain astrocytes aquaporin-4 expre
Hippocampal SPAR expression is associated with intermittent hypoxia-induced enhancement of spatial l
杜继曾的项目