欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
围绕目前全球销售额排名前几位的他汀类降血脂药(HMG-CoA抑制剂)关键手性中间体(3-羟基腈、３-羟基酸或３-羟基内酯)的生物制造技术，设计新的合成路线、合成新的反应底物，从丰富多样的天然酶库或人工变体库中定向筛选新型和高度立体选择性的药物合成用生物催化剂(例如腈水解酶、内酯水解酶和/或Baeyer-Villiger单加氧酶等)，并对酶进行分离纯化表征和催化性能优化；在此基础上构建适宜的反应介质和反应器系统，批量合成降脂药的手性侧链(beta-羟基酸)。研究成果不仅可进一步丰富和发展现有的酶学知识与应用范围，而且可能获得我国独有的、具有自主知识产权的生物催化剂新品种与新工艺，对促进我国药物化工/精细化工重大产品生物制造产业的高起点和跨越式发展将具有十分重要的意义。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Efficient reduction of aromatic ketones with NADPH regeneration by using crude enzyme from Rhodotoru
Investigating pH and Cu (II) effects on lipase activity and enantioselectivity via kinetic and spect
Identification, purification and characterization of β-glucosidase from apple seed as a novel cataly
Synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl grou
Immobilization of Serratia marcescens lipase and catalytic resolution of trans-3-(4’-methoxyphenyl)g
Significantly enhanced production of Serratia marcescens lipase in fermenter by improving oxygen sup
Asymmetric reduction of ketones by employing Rhodotorula sp. AS2.2241 and synthesis of the β-blocker
Enantioconvergent hydrolysis of styrene epoxides by newly discovered epoxide hydrolases in mung bean
Facile synthesis of alkyl β-D-glucopyranosides from D-glucose and the corresponding alcohols using f
Isolation and properties of a levo-lactonase from Fusarium proliferatum ECU2002: a robust biocatalys
Enzymatic transformation of ginsenoside Rg3 to Rh2 using newly isolated Fusarium proliferatum ECU204
Preparation of (R)-(-)-mandelic acid and its derivatives from racemates by enantioselective degradat
会议论文
An organic solvent tolerant lipase from Serratia marcescens ECU1010: biochemical characterization an
Construction of Fibrous Bed Bioreactor with Immobilized Fusarium Proliferatum Lactonase for Producti
Assembly a three- dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous m
Cloning and expression of a nitrilase gene from Alcaligenes sp. strain ECU0401 for production of (R)
Isolation and properties of a novel beta-glucosidase from Fusarium proliferatum CGMCC1495 hydrolyzin
Isolation of esterase-producing microorganisms to enantioselectively hydrolyze 2-acetoxy phenylaceti
Biocatalytic Synthesis of Glycolic Acid from Glycolonitrile by a Newly Isolated
Nitrilase-producer A
Characterization of Glycolate Oxidase from Medicago falcata Linn and its Application in
the Producti
Enzymatic preparation of l-menthol by a high concentration substrate tolerable esterase from a newly
Efficient reduction of aromatic ketones with NADPH regeneration using Rhodotorula sp. cell extract a
Immobilization of a novel glycolate oxidase on magnetic nanoparticles for production of glyoxylic ac
相关项目
许建和的项目