中文摘要：

目的：对比观察连翘提取物的解热作用,探讨连翘提取物研究中适用的发热模型及推测可能的作用机制。方法：建立酵母（2 g/kg）、脂多糖（LPS）（20μg/kg）致大鼠发热模型,分别测量大鼠的肛温,考察造模后灌胃给药10m L/kg生理盐水、0.2 g/kg阿司匹林、1.25,2.5,5 g/kg连翘提取物后不同时间内大鼠的体温变化。结果：酵母和LPS致热模型制作成功,1.25,2.5 g/kg连翘提取物对发热模型动物的体温影响较小,5 g/kg连翘提取物和阿司匹林可减缓发热模型动物的体温升高趋势,对LPS致热模型的解热作用更显著。结论：连翘提取物对酵母和LPS致热模型有解热作用,对LPS致热模型的解热作用较酵母致热模型更显著,推测其可能是通过抑制PGE2的合成和释放来发挥解热作用。

英文摘要：

Objective：To compare the antipyretic effects of Forsythia extract on different febrile model rats and speculate the antipyretic mechanism. Methods ：Febrile models were established by yeast（2 g/kg）or LPS（20 μg/kg）in the study. The rat rectal temperature was measured after oral administered with normal saline （ 10 mL/kg）, aspirin （0.2 g/kg）, Forsythia extract （ 1.25, 2. 5,5 g/kg）at different time respectively. Results： Yeast- induced febrile model and LPS- induced febrile model were established successfully. Forsythia extract （5 g/kg）and aspirin （0.2 g/kg） decreased the temperature in febrile model rats. While For- sythia extract （ 1.25,2. 5 g/kg）didnotshow a significant antipyretic effect. Conclusion：These findings suggest that Forsythia extract possesses antipyretic activity on yeast - induced, LPS - induced febrile model ratsand the antipyretic effect on LPS - induced febrile model rats is more significant. The mechanism of Forsythia extract may be related to the inhibition of synthesis and release of PGE2.