中文摘要：

目的：研究大黄附子组分配伍对附子总生物碱在阳虚便秘大鼠体内的药动学行为的影响。方法：将阳虚便秘大鼠分为附子组和配伍组,附子组灌胃9.6 mg·kg~（-1）附子总生物碱,配伍组灌胃9.6 mg·kg~（-1）附子总生物碱、19.2 mg·kg~（-1）大黄总蒽醌,UHPLC-Q/TOF-MS法测定附子总生物碱的血药浓度,并计算药动学参数。结果：配伍后乌头碱、新乌头碱和次乌头碱的C_（max）、AUC_（last）明显降低,T_（max）明显提前;苯甲酰乌头原碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱和乌头原碱的C_（max）、AUC_（last）明显升高,T_（max）明显延后,差异有统计学意义（P〈0.05或P〈0.01）。结论：大黄总蒽醌、附子总生物碱组分配伍后改变了附子总生物碱在阳虚便秘大鼠体内的药动学行为。

英文摘要：

Objective ： To study the effect of the compatibility of Fuzi total alkaloids and rhubarb anthraquinones on pharmaco- kinetics of Fuzi total alkaloids in rats with insufficiency of spleen - Yang and kidney - Yang in vivo. Methods ： The constipation rats were divided equally into Fuzi group and compatibility group. Fuzi total alkaloids with the dose of 19.2 mg kg-1 were orally ad- ministered to Fuzi group, and 19.2 mg kg-l Fuzi total alkaloids and 38.4 mg kg- 1 rhubarb anthraquinones were given to com- patibility groups, respectively. The contents of Fuzi total alkaloids in rats plasma were detected by using a UHPLC - Q/TOF - MS method, and winnonlin 6.3 was taken to estimate pharmacokinetic parameters. Results ： The pharrnacokinetic parameters of aconi- tine,mesaconitine and hypaconitine obtained showed that Cmax and AUClast were obviously decreased and Tmax was advanced after compatibility. With the significant increased Cmax and AUClast, Tmax of benzoylaconine, benzoylmesaconine, benzoylhypaeonine and aconine were remarkably delayed in compatibility group than that in Fuzi group. The difference was statistically significant （ P 〈 0. 05 or P 〈 0. 01 ）. Conclusion ：There was obvious effect on pharmacokinetic behavior of Fuzi total alkaloids in constipation rats when it was combined with rhubarb anthraquinones.