中文摘要：

近几年研究发现长链非编码RNA（10ngnon—coding RNA，IncRNA）在肿瘤的发生发展过程中发挥着重要的作用。IncRNA是一类转录本长度大于200个核苷酸不编码蛋白质的RNA分子，在正常细胞与肿瘤细胞的基因表达调节中起着重要作用，lncRNA与肿瘤细胞的增殖、浸润、转移和复发密切相关。在膀胱癌中lncRNA可以作为检测指标及预后因子，有望成为疾病治疗的新靶点。本文对lncRNA在膀胱癌中的研究进展进行综述，探讨lncRNA在调控膀胱癌发生发展中的作用机制。

英文摘要：

Recently, several studies have found that long non-coding RNA （lncRNA） plays an important role in the progress of cancer development, lncRNAs are longer than 200 bp and without protein coding capacity, which are in- volved in important gene expression regulation at normal and cancer cells, lncRNAs are closely related to tumor cell pro- liferation, invasion, metastasis and recurrence. IneRNAs may be a potential novel therapeutic target as a diagnostic mark- er and prognostic factor in bladder carcinoma. This paper summarized the research progress about lncRNAs in bladder carcinoma to explore the mechanism of the regulation of bladder carcinoma development by lneRNAs.