中文摘要：

萘普生是一种非常重而且有效的非甾体类消炎药,广泛应用于治疗疼痛、发热等症状.文章考察了新型手性N杂双膦配体（BIQAP）在不对称催化氢化制备萘普生中的应用研究,通过配体与金属钌形成手性催化剂,经过一系列条件的筛选,结果表明,在32℃、10 MPa H2、甲醇做溶剂、三乙胺做助剂的条件下,Ru（RBIQAP）（OAc）2能够有效地催化萘普生前体2-（6＇-甲氧基-2＇-萘基）丙烯酸,并取得了较高的收率（99%）和良好的对映选择性（81.7%ee）.

英文摘要：

Naproxen is one of the important and effective nonsteroidal antiinflammatory drugs and widely used in pain and fever treatment.A novel chiral biphosphine ligands 6,6′-bis（diphenylphosphino）-5,5′-biquinoline （BIQAP）coordinate with Ru were successfully applied in asymmetric catalytic hydrogenation of 2-（6′-methoxy-2′-naphthyl）propenoic Acid in this paper.After a series of experiments,the results show that in the condition of 32 ℃,1 0 MPa H2 ,methanol as the solvent,the additive is Et3 N,Ru（R-BIQAP）（OAc）2 as the catalyst.Op-tically pure naproxen with up to 81 .7% enantiomeric excess were obtained in high yield （99%）.