中文摘要：

低剂量纳曲酮作为一种新型抗炎制剂,可通过小胶质细胞对中枢神经系统起作用,它能够减轻纤维肌痛症,克罗恩氏病,多发性硬化症等疾病症状。作为一种日用口服制剂,纳曲酮便宜且耐受性好,但用它治疗慢性疾病仍需多次试验。低剂量纳曲酮可能是用于治疗慢性疼痛的第一代神经胶质细胞调节器之一。本文将介绍低剂量纳曲酮在临床试验中的典型用法和优缺点。

英文摘要：

via action on microglial cells.It can reduce symptom severity in conditions such as fibromyalgia,Crohn＇s disease,multiple sclerosis. As a daily oral therapy, LDN is inexpensive and well-tolerated, but the use of LDN for chronic disorders is still highly experimental. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.This review will cover the typical usage of LDN in clinical trials and its advantages and disadvantages.