中文摘要：

目的：利用功能磁共振成像技术研究正常人及单侧长期感音神经性聋患者调幅音刺激任务时听觉皮层的激活,探讨单侧长期感音神经性聋患者听觉皮层优势半球的变化及可能存在的功能重组。方法：对11例健康受试者及21例单侧长期重度感音神经性聋患者分别进行正弦调幅音任务下的功能磁共振扫描,实验刺激声音为500 Hz的载波频率,8 Hz的正弦调幅音。正常对照组分别左、右耳呈现;耳聋组于健耳呈现。采用事件相关Sparse设计采集数据以减少扫描噪音,运用SPM2软件对数据进行统计学分析,得到脑功能活动的图像。结果：正常人组单耳刺激时,对侧听觉皮层激活容积及激活强度均明显大于同侧,表现为明显的对侧半球优势;耳聋组健耳刺激时,双侧听觉皮层均有激活,但仍为对侧优势。结论：听觉中枢具有可塑性,单侧感音神经性聋患者听觉皮层存在着结构重组。

英文摘要：

Objective：Amplitude modulation of auditory cortical responses was evaluated with functional MRI（fMRI） in subjects of unilateral sensorineural hearing loss（USNHL） and those of normal hearing（NH）.Method：Twenty-one subjects with USNHL and 11 with normal hearing were examined with fMRI in response to amplitude modulatin tones of 500 Hz with the modulation frequency at 8 Hz.An event related design was combined with a sparse clustered volume acquisitioning paradigm in data collection in order to reduce the influence of acoustic scanner noise.SPM2 software was used for offline data analyzing.Result：Significant activation,including volume and intensity,were found in the temporal lobe of control subjects,and significant differences in the volume and intensitywere noted between the contralateral and ipsilateral activated auditory cortexes in them,exhibiting clearly contralateral predominance.When the normal ear with unilateral sensorineural hearing loss received signals,while significant activations in bilateral auditory cortexes,greater activation in the contralateral auditory cortexes was found in the normal ear.Conclusion：The difference in the lateralization between the two groups suggests the plasticity of auditory cortex with unilateral sensorineural hearing loss.