中文摘要：

目的评价黄芪建中汤治疗消化性溃疡的有效性。方法计算机检索中国知网（CNKI）（1979～2016）、维普网（VIP）（1989～2016）和万方数据知识服务平台（WF）（1998～2016）。将临床随机对照试验（RCTs）中所有关于黄芪建中汤与西药治疗进行对照的文献纳入,依照Cochrane Review Handbook 5.3对纳入的研究进行的质量评估由两名评价者分别独立完成。统计学分析采用软件Rev Man5.3.5进行。结果共18篇文献,2030例患者被纳入。Meta分析结果示：1）临床总有效率：黄芪建中汤配合三联疗法对照单用三联疗法,相对危险度[RR=1.11,95%CI（1.05,1.18）]（P=0.0002）;黄芪建中汤配合拉唑类药物对照单用拉唑类药物,相对危险度[RR=1.14,95%CI（1.06,1.22）]（P=0.0005）,上述差异均有统计学意义。2）临床治愈率：黄芪建中汤配合三联疗法对照三联疗法,相对危险度[RR=1.28,95%CI（1.11,1.49）]（P=0.0010）,差异有统计学意义。3）复发率：黄芪建中汤对照拉唑类药物,相对危险度[RR=0.33,95%CI（0.18,0.63）]（P=0.0008）;对照组在单用拉唑类药物基础上,根据Hp感染情况,酌情加用三联疗法,试验组在该治疗方案基础上加用黄芪建中汤,相对危险度[RR=0.09,95%CI（0.01,0.66）]（P=0.02）;黄芪建中汤配合三联疗法对照单用三联疗法,相对危险度[RR=0.29,95%CI（0.15,0.57）]（P=0.0003）。上述差异均有统计学意义。4）Hp清除率：黄芪建中汤单用对照单用拉唑类药物疗法,相对危险度[RR=2.60,95%CI（1.73,3.91）]（P〈0.00001）;黄芪建中汤配合拉唑类药物对照单用拉唑类药物,相对危险度[RR=1.10,95%CI（1.01,1.21）]（P=0.04）,上述差异均有统计学意义。结论黄芪建中汤治疗消化性溃疡相比单纯使用西药治疗有一定优势,如提高临床有效率、临床治愈率、Hp清除率及降低复发率等。

英文摘要：

Objective： To evaluate the efficacy of Huangqi Jianzhong decoction in treating peptic ulcer. Methods： All randomized controlled trials（RCTs） including Huangqi Jianzhong decoction versus western medicine control group in treating peptic ulcer were retrieved from CNKI（1979 to 2016）,VIP（1989 to 2016）,and WANFANG Database（1998 to 2016）. The quality of the included studies was independently assessed by two reviewers according to the Cochrane Review Handbook 5.3. The data were analyzed by Rev Man 5.3.5 software. Results： A total of 18 literatures involving 2030 patients were included. Meta-analyses showed that： 1）Clinical efficacy rate：Huangqi Jianzhong decoction with OAC versus OAC group,[RR=1.11,95%CI（1.05,1.18）],P = 0.0002;Huangqi Jianzhong decoction with class of prazole medicion group versus class of prazole medicion group, [RR=1.14,95%CI（1.06,1.22）],P = 0.0005;all the differences were of significance in statistics science. 2）Clinical cure rate：Huangqi Jianzhong decoction with OAC versus OAC group,[RR=1.28,95%CI（1.11,1.49）],P = 0.0010,the differences had statistical significance. 3）Recurrence rate： Huangqi Jianzhong decoction versus class of prazole medicion group,[RR=0.33,95%CI（0.18,0.63）],P = 0.0008;the control group which used class of prazole medicion would be treated with OAC considering the Hp infection status. The experimental group was given Huangqi Jianzhong decoction based on the control group＇s treatment program,[RR=0.09,95%CI（0.01,0.66）],P = 0.02;all of the differences was of significance in statistics science. 4）Hp clearance rate： Huangqi Jianzhong decoction group versus OAC group,[RR=2.60,95%CI（1.73,3.91）],P 0.00001;Huangqi Jianzhong decoction with class of prazole medicion group versus class of prazole medicion group, [RR=1.10,95%CI（1.01,1.21）],P = 0.04;all of the differences was of significance in statistics science. Conclusion： Huangqi Jianzhong decoction in the treatment of peptic ulcer has certain advantages compared with us