中文摘要：

4H,6H-[1，2，5]噁二唑并[3，4-d]嘧啶-5，7-二酮1-氧化物（1）和6-甲基-4H,6H-[1，2，5]噁二唑并[3，4-d]嘧啶-5，7-二酮1-氧化物（2）是一氧化氮（NO）供体，将它们分别在无溶剂条件下与高温熔融的全乙酰基保护的核糖、木糖、葡萄糖进行糖基化反应，分别得到相应的噁二唑并[3，4-d]嘧啶核苷类化合物7，9～12，化合物7经NH3-MeOH处理，去O-乙酰基制得8，这些新型核苷化合物可作为潜在的NO供体．部分此类化合物的生物活性研究表明，嘧啶并呋咱核苷衍生物具有抗病毒、抗肿瘤活性，为研究抗病毒、抗肿瘤药物提供了新结构类型的候选化合物．

英文摘要：

4H,6H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide （1） and 6-methyl-4H,6H-[1,2,5]- oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide （2） are nitric oxide （NO） donors. Their glycosidation, with peracetyl ribofuranose, xylfuranose and glucopyranose respectively, under solvent-free and fusion reaction conditions gives corresponding oxadiazolo[3,4-d]pyrimidine nucleoside derivatives 7, 9-12. The O-acetyl groups in nucleoside 7 are removed by the use of methanolic ammonia to yield compound 8. These new nucleosides may be as potential NO donors. Initial bioactivity tests show that pyrimidofuroxan-nucleosides have antivirus and anticancer effects. The research results provide new candidate molecules for study of antivirus and anticancer drugs.