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药物合成策略的近期发展
  • 期刊名称:药学进展,2008,32(10):433-440
  • 时间:0
  • 分类:R914[医药卫生—药物化学;医药卫生—药学]
  • 作者机构:[1]中国药科大学药物化学教研室,江苏南京210009
  • 相关基金:国家自然科学基金资助项目(30572240);国家基础科学人才培养基金项目(NFFTBS,J0630858)
  • 相关项目:噁二唑并[3,4-d]嘧啶苷类的合成及其生物活性研究
中文摘要:

综述正向合成分析、动态组合化学、绿色化学、不对称合成等药物合成策略的基本概念、原理及其应用,并介绍了近年来的相关进展。世纪之交出现的新观点、新方法和新技术使药物合成领域得到了前所未有的丰富和发展,尤其在药物合成策略方面最为突出。

英文摘要:

Recently, new idea, novel method and novel but the development of drug synthesis strategies is more technique in drug synthesis have been enriched, important. The basic concepts and principles of these items such as forward-synthetic analysis, dynamic combinatorial chemistry, green chemistry, asymmetric synthesis and so on were reviewed, and their applications to drug synthesis strategy were also discussed. The correlative examples which had been reported in recent years were also introduced.

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