中文摘要：

目的探讨益气温阳活血化瘀方药心复康口服液对慢性压力负荷性心力衰竭大鼠心肌线粒体腺苷酸转位酶（ANT）的影响。方法将90只雄性SD大鼠按随机数字表法分为假手术组、模型组、治疗组，每组30只。采用腹主动脉缩窄法制作慢性压力负荷性心力衰竭大鼠模型；假手术组仅穿线、不结扎。治疗组于术后1周灌胃心复康口服液（10ml·kg^-1·d^-1）4ml；模型组及假手术组灌胃等量生理盐水。于治疗4、8、12周取大鼠心肌组织，采用逆转录一聚合酶链反应（RT—PCR）检测心肌线粒体ANTl和ANT2的mRNA表达。结果与假手术组比较，模型组4、8、12周心肌线粒体ANT1mRNA表达逐渐升高，ANT2mRNA表达逐渐降低，分别于12周达峰值和谷值，差异有统计学意义（ANT1mRNA：28．44±0．04比27．32±0．49；ANT2FiRRNA：21．40±0．12比23．97±0．05，均P〈0．05）；与模型组比较，治疗组ANT1和ANT2的mRNA表达均逐渐升高，并于12周达峰值（ANT1mRNfA：29．39±0．15；ANT2mRNA：23．83±0．20），差异有统计学意义（均P〈0．05）。结论心复康口服液能通过改善慢性压力负荷性心力衰竭心肌ANT1、ANT2的表达，从而抑制细胞凋亡、改善能量代谢。

英文摘要：

Objective To investigate the effect of Xinfukang oral liquid （心复康口服液） with actions of supplementing Qi （益气）, warming yang （温阳）, promoting blood circulation and removing blood stasis （活血化瘀） on adenine nucleotide translocator （ANT） in myocardial mitochondria of rats with chronic pressure overload heart failure induced by partial coarctation of abdominal aorta. Methods Ninety male Sprague- Dawley （SD） rats were randomly divided into three groups： sham operation, model and treatment groups （each, n = 30）. Chronic pressure overload heart failure model was reproduced by partial eoarctation of abdominal aorta, and rats in sham operation group received an operation with only the penetration of a thread without coarctation of abdominal aorta. One week after operation, 4 ml Xinfukang oral liquid （10 ml · kg^- 1 . d ^-） began to be administered into the stomach in the treatment group, and the same amount of normal saline was given in model and sham operation groups. The myoeardium was harvested at 4, 8, 12 weeks after treatment, and the mRNA expressions of ANT1 and ANT2 were detected from myocardial mitochondria by reverse transcription-polymerase chain reaction （RT-PCR）. Results Compared with sham operation group, the ANT1 mRNA expression was significantly increased, while the ANT2 mRNA expression was obviously decreased in model group at 4, 8, 12 weeks after treatment, and they reached the highest and lowest value at 12 weeks, respectively （ANT1 mRNA： 28.44 ± 0.04 vs. 27.32 ± 0.49; ANT2 mRNA： 21.40±0.12 vs. 23.97±_ 0.05, both P（0.05）. Compared with model group, the expressions of ANT1 mRNA and ANT2 mRNA were markedly increased at 4, 8, 12 weeks after treatment in treatment group, and they peaked at 12 weeks （ANT1 mRNA; 29.39 ±0.15; ANT2 mRNA： 23.83± 0.20, both P〈0.05）. Conclusion Xinfukang oral liquid can inhibit the cell apoptosis and enhance the energy metabolism through improving the expressions of ANT1 mRNA and ANT2 mRNA in chro