中文摘要：

目的研究中药复方制剂心复康口服液对压力负荷型充血性心力衰竭（CHF）大鼠心肌细胞葡萄糖转运蛋白4（GLUT4）的影响，探讨中药改善心肌能量代谢的机制。方法将60只SD大鼠随机分为假手术组（SH）、腹主动脉缩窄模型组（CAA）、心复康口服液治疗组（XFK），每组20只。复制压力负荷型CHF大鼠模型，分别于药物干预6周、10周时检测各组大鼠心功能参数、心肌细胞GLUT4蛋白表达。结果制模6周、10周时CAA组大鼠心功能明显降低，左室舒张期末压（LVEDP）、左室重量指数（LVMI）显著升高，左心室内压上升、下降最大变化速率±dp／dt max）显著下降（P均〈0．01）；XFK组大鼠心功能各项指标较CAA组明显改善（P均〈0．01）；10周时LVEDP、LVMI下降及＋dp／dtmax升高较6周时更为显著（P〈0．05或P〈0．01），而-dp／dtmax则无明显变化。CAA组6周与10周时GLUT4较SH组显著下降；XFK组较cAA组显著升高（P均〈0．01），且10周时GLUT4蛋白表达较6周时明显升高（P〈0．01）。结论具有益气温阳、活血化瘀作用的心复康口服液对压力负荷型CHF大鼠心功能及心肌细胞GLUT4表达具有明显的改善作用。

英文摘要：

Objective To investigate the effect of traditional Chinese medicine （TCM） Xinfukang oral liquid （心复康口服液） on the glucose transporter 4 （GLUT4） of cardiac muscle in rats with pressure overload- induced left ventricular hypertrophy and study its mechanisms of improving myocardial energy metabolism. Methods The models of congestive heart failure （CHF） were established by constricting the abdominal aorta of rats partly. Sixty Sprague-Dawley （SD） rats were randomly divided into sham operation （SH） group, coarctation of abdominal aorta （CAA） model group and Xinfukang oral liquid （XFK） treatment group （each, n=20）. The parameters of cardiac function and quanta of GLUT4 expression in cardiac muscle in every group were respectively measured at the time points of 6th and 10th week after the intervention of the drug. Results ①The study showed that in CAA group, the cardiac function was decreased significantly, left ventrieular end-diastolic pressure （LVEDP） and left ventricular mass index （LVMI） were markedly increased, and the maximum ascending and descending changing rates of the left intra-ventricular pressure （±dp/dt max） was decreased obviously （all P 〈 0. 01）. In the XFK group all kinds of cardiac function parameters were significantly improved compared with those in CAA group （all P〈0.01）3 the LVEDP and LVMI were more significantly decreased, and q-dp/dt max was more obviously increased in XFK group at the 10th than those at the 6th week point （P〈0. 05 or P〈0. 01）, while this comparison did not show any obvious difference in -dp/dt max （P〉0. 05）. ②The study showed that at the time points of 6th and 10th week, GLUT4 expression in XFK group was higher than that in the CAA group （both P〈0.01）. The comparison of GLUT4 expression at the time points of 6th and 10th week in XFK group revealed obvious difference （P（0. 01）. Conclusion TCM Xinfukang oral liquid possessing actions of replenishing Qi （益气）, warming Yang ?