中文摘要：

目的：研究桂枝茯苓胶囊对大鼠子宫内膜异位症（EMs）异位内膜组织中单核细胞趋化蛋白-1（MCP-1）,细胞黏附分子-1（ICAM-1）在蛋白水平和转录水平的影响。方法：改进制作大鼠EMs动物模型,ig桂枝茯苓胶囊0.256,1.024 g.kg^-1,28 d后取子宫内膜,采用免疫组化法检测内膜组织中MCP-1,ICAM-1的分布和表达;采用RT-PCR检测异位内膜组织中MCP-1,ICAM-1 mRNA的表达。结果：桂枝茯苓胶囊可降低大鼠子宫内膜异位内膜组织中MCP-1,ICAM-1的表达;高、低剂量组可使MCP-1,ICAM-1 mRNA水平显著下降（P〈0.01）,两剂量之间无显著性差异。结论：桂枝茯苓胶囊可降低EMS异位内膜组织中MCP-1,ICAM-I的表达,降低其mRNA的表达。

英文摘要：

Objective：To study the effects of Guizhi Fuling Capsule on expression of monocyte chemoattractant protein-1（MCP-1） and inter-cellular adhesion molecule-1（ICAM-1） mRNA of ectopic endometrium in rats with endometriosis.Method：Endometriosis model of rat was created by self-transplant,and then administrated with Guizhi Fuling Capsule（0.256,1.024 g·kg^-1） orally for 28 days.Expression and distribution of MCP-1 and ICAM-1 in ectopic endometrium were observed by immunohistochemistry.The mRNA expression of MCP-1,ICAM-1 were evaluated with RT-PCR.Result：The expression and distribution of MCP-1 and ICAM-1 were significantly decreased after treatment with Guizhi Fuling Capsule.Both dose showed similar effect without significant difference.Conclution：The distribution of MCP-1 and ICAM-1 in ectopic endometrium of endometriosis can be modified by Guizhi Fuling Capsule and the mRNA expression was decreased.