血管生成是人体许多生理病理过程的基础,细胞表面受体整合素家族是调节血管生成的关键因子,与细胞外基质蛋白、免疫球蛋白超家族等配体结合后,传导细胞内外双向信号,从而在血管内皮细胞增殖与移行中发挥重要作用。以整合素为靶点的治疗策略成为血管增殖性疾病防治的研究热点。现就整合素家族在血管形成中的作用及其临床应用前景作一综述。
Angiogenesis is a fundamental physiological and pathological process in human body.Angiogenesis is regulated by integrins,a family of cell surface receptors.After binding with their ligands such as extracellular matrix proteins and immunoglobulin superfamily molecules,integrins can promote the proliferation and migration of endothelial cells during angiogenesis.Several integrin-targeted therapeutic agents are currently used in clinical trials for the therapy of angiogenesis related diseases.Here,there will show the roles of integrins in angiogenesis and clinical application.