中文摘要：

目的探讨牛初乳对免疫抑制小鼠免疫功能的影响。方法将ICR雌性小鼠随机分为五组：正常对照组，模型对照组和牛初乳低、中、高剂量组。观察不同剂量牛初乳对免疫抑制小鼠脾指数、胸腺指数、细胞免疫、体液免疫、单核-巨噬细胞吞噬功能及脾脏T淋巴细胞亚群的影响。结果三个剂量组的脾指数和胸腺指数显著低于正常对照组（P〈0．01）。中、高剂量组脾脏T淋巴细胞增殖能力显著高于模型时照组（P〈0．01）。三个剂量组溶血空斑数均显著高于模型对照组但低、高剂量组低于正常对照组（P〈0．01）。三个剂量组校正后吞噬系数α明显高于模型对照组及正常对照组（P〈0．01）。中剂量组脾脏T淋巴细胞中CD4＋百分比显著高于模型对照组及正常对照组（P〈0．01）。结论牛初乳能够有效提高免疫抑制小鼠细胞免疫、体液免疫、单核-巨噬细胞吞噬功能和脾脏CD4＋百分比。

英文摘要：

Objective To observe the effects of bovine colostrum （BC） on the immunological function in mice. Methods Female ICR mice were randomly assigned into five groups ： normal control group （NC）, model control group （MC）, low, medium, and high dosage BC groups （BL, BM, BH）. Four weeks later, spleen and thymus were weighted, cell~mediated immune function, humoral immune function, phagocytic function of mononuclear phagocyte and the T cell subpopulation in spleen were assayed. Results The spleen and thymus index in BL, BM and BH were drastically decreased in comparition with NC （P 〈 0.01 ）. The capacities of lymphocyte proliferation induced by ConA in BM and BH were obviously higher than those of MC （ P 〈 0.01 ）. The numbers of hemolytic plaques in all three BC groups were larger than those of MC （ P 〈0.01）, yet the values in BL and BH were much smaller than NC （P 〈 0.01）. All the BC groups＇ corrected phagocytic coefficient a were drastically higher than MC and NC （ P 〈 0.01 ）. Lastly, the CD4 ＋ T cell of spleen in BM were greatly higher than MC and NC （ P 〈 0.01 ）. Conclusion Bovine colostrum was efficaciously increase cellular immune level, antibody forming level and phagocytic function of mononuclear phagocyte and the decrease of CD4 ＋ T cell in spleen inhibited by cyclopbosphamide.