中文摘要：

目的研究高含量大豆异黄酮（Soybean lsoflavone,SI）对去卵巢高脂模型大鼠肝X受体a（L iver X receptor,αLXRα）基因表达的影响。方法将48只成年雌性SD大鼠去卵巢,根椐体重和总胆固醇（TC）水平随机分为6组,分别喂饲不同饲料12周 实验结束采集尾血测定其体内血脂水平,并检测大鼠肝脏、小肠中LXRα基因表达情况。结果与高脂模型组比较,大豆异黄酮各剂量组大鼠血中甘油三酯（TG）、TC、低密度脂蛋白胆固醇（LDL-C）水平均降低（P〈0.05）,大豆异黄酮高剂量组高密度脂蛋白胆固醇（HDL-C）水平为（1.71±0.17）mmol/L,明显高于高脂模型组的（1.36±0.21）mmol/L（P〈0.05） 大豆异黄酮高剂量组、雌激素对照组大鼠肝脏中LXRα基因表达明显高于高脂模型组（P〈0.05） 与高脂模型组比较,雌激素对照组大鼠小肠中LXRα基因表达明显升高。结论大豆异黄酮可拮抗高脂饲料对去卵巢大鼠造成的脂代谢紊乱,并促进肝脏中LXRα基因的表达。

英文摘要：

Objective To study the effect of soybean isoflavone on the expressioon of live X receptor a（LXRα） in an ovariectomized rat model of high-fat. Methods Forty-eight female ovariectomized SD rats were divided randomly into 6 groups ： basic control, model, estrogen control, and low, medium, high dose of soybean isoflavone. At the end of trial, the rats were sacrificed and the serum was collected for lipid level detection. The expressions of LXRα in liver and intestine were assessed. Results All doses of soy isoflavone could decrease the level of triglyceride,total cholesterol, and low density lipoprotein-C （ P 〈 0. 05 ）, and only high dose isoflavone could increase the level of high density lipoprotein-C （ P 〈 0. 05 ）. The expression of LXRα varied in different groups. Conclusion Supplementation of soybean isoflavone could protect the rats fed with high-fat diet from damage. Soybean isoflavone also has effect on the expression of LXRα in liver.