中文摘要：

目的：在体外模拟循环实验台测试搏动式血泵的流体力学特性，并通过动物实验论证其可行性，为进一步的临床性研究提供依据。方法：分别利用水和林格氏液作为循环介质，模拟体外循环条件，观察体外模拟循环试验前、后负荷的变化对输出量的影响，并通过动物实验加以论证。结果：在固定前负荷不变的情况下，增大后负荷可使心输出量逐渐下降，而保持后负荷不变的情况下，逐渐加大前负荷，输出量增加不明显。设定前负荷的改变范围为10～50mmHg，后负荷的改变范围为60～110mmHg，测出相应输出量的变化为4．0～5．9L。后期动物实验结果表明该搏动式血泵对心衰猪的心脏功能有一定的辅助作用。结论：搏动式血泵对后负荷增加表现出明显的流量抑制效应，而对前负荷反应则不明显，动物实验亦证实了其有一定的可行性。

英文摘要：

Objective：To test the pulsatile blood pumps in a mock circulation loops, and then to prove its feasibility by animal experiments. Methods： In the mock circuit, the water and Ringerrs solution were used respectively as the circulating mediums to test the performance of the heart assist devices with pulsatile flow pumps, and to prove it by animal experiments. Results：When preload was fixed, cardiac output was gradually decreased with the increase in afterload. While afterload was kept unchanged, cardiac output was almost not affected by the increase in preload. When preload was set between 10 mmHg and 50 mmHg, and afterlood was between 60 mmHg and 110 mmHg, we observed that cardiac output was changed between 4.0 L and 5.9 L. Animal experiments showed that pulsatile blood pump had an supporting role in pigs with heart failure. Conclusion：The study demonstrated that cardiac output of the pulsatile blood pump is significantly restrained by afterload while preload exerts no influence on it. Further investigation is needed to explore the significance of the difference in the load response characteristics.