中文摘要：

以生物可降解聚合物聚（乳酸-羟基乙酸）（PLGA）为载体，以160g／L明胶水溶液为内水相、含500g/LPLGA的二氯甲烷为油相，采用快速膜乳化和溶剂蒸发法制备了粒径均-的载醋酸曲普瑞林PLGA微球，微球粒径约30μm，粒径分布系数昂。〈0．8，醋酸曲普瑞林包埋率达80．12％，药物在磷酸盐缓冲液中释放36d的释放率为72．60％，体外释放行为良好．

英文摘要：

Triptorelin acetate loaded biodegradable poly（lactic-co-glycolic acid） （PLGA） uniform-sized microspheres were prepared by a method combining premix membrane emulsification and solvent evaporation with high concentration （160 g/L） gelatin as water phase and methylene chloride containing high concentration （500 g/L） PLGA as oil phase. It was possible for the drug completely entrapped by the PLGA microcapsules. The mean diameter ofPLGA microspheres was about 30 μm, the encapsulation efficiency of triptorelin acetate 80.12%, and Span （coefficient of size distribution） value less than 0.8. Subsequently, the cumulative release rate of PLGA microspheres loading triptorelin in vitro for 36 d was 72.60%. Furthermore, the release profile of the drug in vitro was well for controlled release.