中文摘要：

采用快速膜乳化法,以二氯甲烷为油相,通过溶剂挥发制孔,在室温下制备了一系列聚乙二醇聚乳酸共聚物（PELA）多孔微球.结果表明,优化的制备条件为：搅拌速度250r/min、油相中PELA浓度50g/L、水/二氯甲烷/PVA水溶液体积比1：2.5：25及mPEG：PLA分子量比1：14,在该条件下可制备粒径均一、尺寸可控的PELA多孔微球,且孔径较大,孔径最大为15.0nm,属介孔材料,可用于蛋白多肽类药物的吸附.

英文摘要：

Uniform-sized poly（ethylene glycol-co-lactide） （PELA） microspheres were prepared by a combined method of solvent evaporation and Shirasu porous glass membrane emulsification at room temperature with dichloromethane as oil phase. The results show that the suitable conditions to prepare the larger pore size and uniform-sized PELA microspheres are： stirring speed 250 r/min, PELA concentration in oil phase 50 g/L, volume ratio of water/dichloromethane/PVA solution 1：2.5：25, and molecular weight ratio of monomethoxy-poly（ethylene glycol） to poly（lactide acid） 1：14. The average pore size of final microspheres is 15 nm, belonging to the mesoporous material, which can be used as drug carrier to adsorb protein or peptide drugs.