中文摘要：

目的探计As2O3磁性纳米微球磁感应加热治疗宫颈癌的作用和机理。方法用培养的SiHa细胞建立裸鼠人宫颈癌移植瘤模型，将研制的As2O3纳米微球、磁性纳米微球、As2O3磁性纳米微球等注入肿瘤细胞接种处，加高频交变磁场磁感应加热治疗3次后，d45实验结束。分析比较3个实验组较对照组的延迟出瘤时间、质量抑制率、肝功能和肾功能情况及肿瘤、瘤周和内脏组织学的改变。同时观察磁流体热疗的升温和恒温效果。结果在高频交变磁场下，As2O3磁性纳米微球组肉眼未见肿瘤生长，该组的肿瘤质量抑制率为99．93％，明显高于As2O3纳米微球组（85．20％，P〈0．01）及磁性纳米微球组（87．72％，P〈0．01）。各实验组裸鼠血清AST、ALT、Bun及Cr水平与对照组相比无显著性差异（P〉0．05），瘤旁和内脏组织未见明显损伤。结论在高频交变磁场作用下，As2O3纳米微球、磁性纳米微球、As2O3磁性纳米微球治疗裸鼠宫颈癌均有效，以As2O3磁性纳米微球效果最佳。本研究所采用的As2O3磁性纳米微球联合磁流体热疗技术具有双重抗癌功能，为宫颈癌和其他实体瘤的治疗提供了一条新途径。

英文摘要：

OBJECTIVE To explore into the effect and mechanism of using As2O3 nanometer microballoon magnetism induced heating in the treatment of cervical carcinoma. METHOD Athymic mouse transplantation tumor models of human cervical carcinoma was made using SiHa cells. As2O3 nanometer microballoons, magnetic nanometer microballoons and As2O3 magnetic nanometer microballoons were then infused into the inoculation location of the tumor cells, which were then heated for 3 times with high - frequency alternating magnetic field. The experiment lasted for 45 days. RESULT Under the high - frequency alternating magnetic field, no tumor growth was detected in the As2O3 magnetic nanometer microballoon group, the tumor growth inhibiting rate being 99.93%, markedly higher than the As2O3 nanometer microballoon group （85.20%, P 〈 0.01 ） and the magnetic nanometer microballoon group （87.72%, P 〈 0.01）. No marked differences were detected between the experimental groups and the control group in serum AST, ALT, Bun and Cr （ P 〉 0.05）. No marked lesion was found in the tissue around the tumors and internal organs. CONCLUSION Under the high - frequency alternating magnetic field, As2O3 nanometer microballoons, magnetic nanometer microballoons and As2O3 magnetic nanometer microballoons are all effective in treating cervical carcinoma, especially As2O3 magnetic nanometer microballoons. As2O3 magnetic nanometer microballoons used in combination with fluid thermotherapy has dual anti- cancer effect.