中文摘要：

客观: 评估在里面 vitro 并且在自我准备的 nanosized Fe2 O3，它在肿瘤过高热有潜在的含意的 vivo 毒性。方法: Fe2O3 nanoparticles 被改进一起沉淀准备，描述它被 TEM 检测， XRD， CMIAS，版本 MTT 试金被用来评估在里面 vitro cytotoxicity 测试；hemolytic 测试被执行估计它是否有血毒性；推迟在的 Fe2O3 无菌 0.9% NaCl intraperitoneally 被注入 Kunming 老鼠计算 LD50；micronucleus (MN ) 被计算识别它是否是 genotoxic。结果: nanoparticles 是有直径从 8 ～ 15 nm 的棕色的球形的粒子，它有好分散和稳定性。实验也证明房间衬里的老鼠成纤维细胞(L-929 ) 上的材料的毒性是 0 - 1 度；它不举办溶血活动；LD50 在 1 ml 暂停的 intraperitoneal 注射以后到达了 5.45 g/kg-1；micronucleus 测试证明它也没有 genotoxic 效果。结论: 结果证明 Fe2O3 nanoparticles 成功地被准备，自我准备的 nanosized Fe2O3 是一种高 biocompatibility 材料并且也许它对在肿瘤过高热的进一步的申请合适。

英文摘要：

Objective：To evaluate the in vitro and in vivo toxicity of self-prepared nanosized Fe2O3, which has the potential implication in tumor hyperthermia. Methods： Fe2O3 nanoparticles were prepared by improving co-precipitation, which characterization was detected by TEM, XRD, CMIAS, EDS. MTT assay was used to evaluate the in vitro cytotoxicity test; hemolytic test was carried out to estimate whether it has blood toxicity; Fe2O3 suspended in sterile 0.9% NaCl was intraperitoneally injected into Kumning mouse to calculate the LD50 ; micronucleus （MN） were reckoned to identify whether it is genotoxic. Results：The nanoparticles are brown spherical particles with diameter ranging from 8 to 15 nm, which have good decentralization and stability. The experiments also showed that the toxicity of the material on mouse fibroblast （L-929） cell lines was 0 - 1 degree ; it has no hemolysis activity; LD50 arrived at 5.45 g/kg^-1 after intraperitoneal injection of 1 ml suspension; micronucleus test showed that it has no genotoxic effects either. Conclusion： The results showed that the Fe2O3 nanoparticles are prepared successfully, the self-prepared nanosized Fe2O3 is a kind of high biocompatibility materials and perhaps it is suitable for further application in tumor hyperthermia.