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中文摘要：
光敏感的纳米载体因其可从时间和空间上精确地控制药物的释放以实现对肿瘤的高效治疗,近年来逐渐成为生物医学领域的研究热点之一。本文综述了光敏感的纳米载体破裂从而释放出装载的药物的三种机理,主要包括：（1）光致异构化引发的纳米载体形态转变;（2）光反应引发的纳米载体降解;（3）光热引发的纳米载体破裂。本文简单介绍了这三种释放机理,例举了这三种释放机理所对应的光敏感材料,并阐述了其在药物运输、可控释放以及肿瘤治疗中的最新研究进展以及存在的问题,为光敏感纳米载体在生物体系中的应用提供参考,并对今后的发展作了展望。
英文摘要：
The study of light-responsive nanocarriers is becoming one of the hottest topics in biomedical field due to their precise control of drug release for cancer therapy in spatiotemporal level. This contribution systematically review ed three mechanisms for controlled drug release of photosensitive nanocarriers, including（ 1）photoisomerization caused morphological transformation of nanocarriers,（ 2） photoreaction caused degradation of nanocarriers,and（ 3） photothermal caused disruption of nanocarriers. This review briefly introduced the three mechanisms and their corresponding photosensitive materials. In addition,the recent research developments and problems remained of photosensitive materials for drug delivery and controlled release w ere pointed out. This review also provided useful references for photosensitive nanocarriers in biological applications and the research prospects w ere further proposed.
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