中文摘要：

三磷酸腺苷结合盒超家族G成员2（ABCG2）基因定位于4q22，以同源二聚体形式执行完整转运功能，在保护细胞及机体免受各种内外源物质伤害等方面起着重要作用，其功能发挥受自身结构、机体微环境及性激素等多种因素的影响。它参与了侧群（SP）干细胞表型形成，还与肿瘤的化疗耐药及肿瘤的发生密切相关。

英文摘要：

ATP-binding cassette superfamily G member 2 （ABCG2） gene resides on chromosome band 4q22. ABCG2 is a complete-transporter in homo-dimer form and is believed to play a major role in protecting cells and human body from exogenous and endogenous toxins. The function of ABCG2 is influenced by several factors such as the structure of itself,internal environment and sex hormones. ABCG2 participates the formation of side population stem cells phenotype, and is thought to relate with the multi- drug resistance of tumors and tu- morigenesis.