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Knocking-down of the levels of prion protein by RNA interference (RNAi) weakened the protective acti
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  • 相关项目：朊病毒（PrP）蛋白在生理和病理状态下剪切机制及毒性研究
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朊病毒（PrP）蛋白在生理和病理状态下剪切机制及毒性研究
期刊论文 37
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Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie i
CtmPrP and ER stress: a neurotoxic mechanism of some special PrP mutants.
Immune responses in wild-type mice against prion proteins induced using a DNA prime-protein boost st
Raised levels of tau protein in CSF of Chinese patients with probable diagnostic Creutzfeldt-Jakob d
The octarepeats of hamster PrP (PrP51-91) enhance the formation microtubule and antagonize Cu2+-indu
PrPSc of scrapie 263K propagates efficiently in spleen and muscle tissues with protein misfolding cy
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule str
Familial CJD associated PrP mutants within transmembrane region induced retention of Ctm-PrP in ER a
Clinical, histopathological and genetic studies in a family with fatal familial insomnia.
The first Chinese case of Creutzfeldt-Jakob disease patient with R208H mutation in PRNP.
A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the cha
The epidemiological, clinical and laboratory features of sporadic Creutzfeldt-Jakob disease patients
A Chinese Creutzfeldt-Jakob disease patient with E196K mutation in PRNP.
EV71 viral secretion on symptomatic HFMD patients or asymptomatic close contact personnel.
Establishment and identification of hamster- and human-PRNP transgenic mice.
The diversities of PrPSc distributions and pathologic changes in various brain regions from a Chines
Comparative peptidome analyses of the profiles of the peptides ranging from 1 to 10 KD in CSF sample
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possi
Heat shock protein 104 inhibited the fibrillization of prion peptide 106-126 and disassembled prion
Transient expressions of doppel and its structural analog prionΔ32-121 inSH-SY5Y cells caused cytoto
Molecular interaction of alpha-synuclein with tubulin influences onthe polymerization of microtubule
Changes of tau profiles in brains of the hamsters infected with scrapie strains263K or 139A possibly
Manganese induced changes of the biochemical characteristics of therecombinant wild-type and mutated
Cytosolic prion protein induces apoptosis inhuman neuronal cell SH-SY5Y via mitochondrial disruption
The propagation of hamster-adapted scrapie PrPSc can be enhanced by reduced pyridine nucleotide in v
Human prion protein mutants with deleted and inserted octarepeats undergo in different pathways to t
The prepared tau exon-specific antibodies revealed distinct profiles of tau in CSF of the patients w
朊病毒病相关细胞凋亡
Establishment of a Stable PrP^Sc Panel from Brain Tissues of Experimental Hamsters with Scrapie Strain 263K
人doppel蛋白及其类似蛋白PrPΔ32-121对SH-SY5Y细胞的细胞毒性作用
Establishment of Hamster- and Human-PRNP Transgenic Mice
Clinical and Familial Characteristics of Ten Chinese Patients with Fatal Family Insomnia
Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy
Casein kinase Ⅱ interacts with prion protein in vitro and forms complex with native prion protein in vivo