中文摘要：

目的探讨脓毒症患者血小板检测的临床意义。方法选择2013年3月-2015年10月脓毒症患者78例的临床资料进行回顾性分析。比较存活患者与死亡患者血小板（PLT）参数差异，比较不同APACHEⅡ评分患者血小板参数差异，分析血小板参数与APACHEⅡ评分的相关性。结果存活组患者PLT计数显著高于死亡组，血小板平均容积（MPV）、血小板分布宽度（PDW）、大型血小板比率（P—LCR）、APACHEⅡ显著低于死亡组，差异均有高度统计学意义（P〈0．01）。APACHEⅡ评分〈10分组患者PLT计数显著高于10—19分组及≥20分组，MPV、PDW、P—LCR水平显著低于10-19分组及≥20分组，差异有高度统计学意义（P〈0．01）；10-19分组计数显著高于≥20分组，MPV、PDW、P—LCR水平显著低于≥20分组，差异有高度统计学意义（P〈0．01）。APACHEⅡ与血小板计数呈显著负相关的关系（r=-0．511）：APACHEⅡ与MPV呈显著正相关的关系（r=0．472）：APACHEⅡ与血小板分布宽度呈显著正相关的关系（r=0．468）；APACHEⅡ与大型血小板比率呈显著正相关的关系（r=0．449）。结论脓毒症患者血小板计数、MPV、PDW、P-LCR可反映患者的病情，可用于评估预后，对临床诊断和治疗具有指导意义。

英文摘要：

Objective To discuss clinical significance of platelet parameters in condition assessment and prognosis evaluation of sepsis. Methods Clinical data of 78 cases with sepsis from Mar 2013 to Oct 2015 were respectively analyzed. Platelet parameters between death group and survive group were compared; Platelet parameters in groups of different APACHE 11 were compared. Results PLT count of survive group was higher than death group, and MPV, PDW,P-LCR,APACHE Ⅱ were lower than death （P〈0.01）. PLT count of group of APACHE Ⅱ 〈10 was higher than group of 10-19 and group of ≥20, and MPV, PDW,P-LCR were lower than group of 10-19 and group of ≥20 （P〈 0.01）; PLT count of group of 10-19 was higher than group of ≥20, and MPV, PDW,P-LCR were lower than group of ≥ 20 （P〈0.01）. APACHE Ⅱ was significantly negative correlation with platelet count （r=0.511） ; APACHE Ⅱ was significantly positive correlation with MPV （r=0.472） ; APACHE Ⅱ was significantly positive correlation with PDW （r= 0.468） ; APACHE Ⅱ was significantly positive correlation with P-LCR （r =0.449）. Conclusion Platelet parameters, MPV, PDW and P-LCR of sepsis reflect condition, and can be used to evaluate prognosis, to guide the clinical diagnosis and treatment.