中文摘要：

目的：探讨脓毒症患者血浆血小板活化因子（PAF）与皮质醇（Cor）水平的相关性以及临床意义。方法：选择2013年1月-2015年12月在我院住院治疗的脓毒症患者89例为研究对象,另选择健康体检者60例为对照组。比较脓毒症组患者与对照组血浆PAF及Cor水平,比较不同严重程度患者、不同结局患者血浆PAF及Cor水平以及其他炎性指标、危重症评分;分析不同严重程度患者血浆PAF及Cor水平与炎性指标及危重症评分的相关性,分析对照组、不同严重程度脓毒症患者、不同结局脓毒症患者PAF与Cor的相关性;分析脓毒症患者血浆PAF及Cor水平对患者结局预测的灵敏度及特异度。结果：脓毒症患者血浆PAF及Cor水平均显著高于对照组,差异有统计学意义（P〈0.01）。不同严重程度患者PCT、Cr、PAF、Cor、APACHEⅡ、SOPA、SAPSⅡ、死亡率比较差异有统计学意义（P〈0.01）。脓毒症患者PAF水平及Cor与炎性指标及危重症评分具有显著正相关的关系（P〈0.01）。以PAF≥2.15μg/L为界点,对患者结局预测的灵敏度53.9%,特异度80.9%。Cor≥351.61μg/L为界点,对患者结局预测的灵敏度86.5%,特异度64.0%。总脓毒症患者、不同严重程度脓毒症患者以及不同结局脓毒症患者血浆PAF与Cor水平均具有显著正相关的关系（P〈0.01）。结论：脓毒症患者血浆PAF及Cor水平升高,两者呈正相关的关系,并且与患者严重程度及结局有关,可用于评价患者病情以及预测患者预后。

英文摘要：

Objective： To discuss correlation and its clinical significance of plasma platelet activating factor and cortisol levels in patients with sepsis. Methods： From January 2013 to December 2015,89 cases of sepsis patients in our hospital were selected as the study subjects,and the other 60 cases with healthy physical examination were selected as the control group. Plasma PAF and Cot levels in patients with sepsis and controls were compared;Plasma levels of PAF and Cor as well as other inflammatory parameters, critical illness score in patients with different levels of severity and in patients with different outcomes were compared. The correlation between the levels of plasma PAF and Cor levels with the inflammatory markers and the severity score in patients with different severity were analyzed; The correlation between PAF and Cor with different outcome in the control group and patients with sepsis were analyzed. The sensitivity and specificity of plasma PAF and Cot levels in patients with sepsis were analyzed. Results： The levels of plasma PAF and Cor in the patients with sepsis were significantly higher than those in the control group, the difference was statistically significant （P〈0. 01 ）. There were significant differences in PCT, Cr, Cor, APACHE Ⅱ , SOPA, SAPS Ⅱ , and PAF in patients with different severity （P〈0. 01）. The relationship between PAF levels and Cot levels with inflammatory markers and critical illness scores in patients with sepsis were significantly positively correlated （P〈0. 01）. With PAF more than 2. 15μg/L as the boundary points, the sensitivity of the 53. 9% patients outcome prediction, specificity 80. 9%. With Cor more than 351.61μg/L as the boundary points, the sensitivity of the 86.5% patients outcome prediction, specificity 64%. The plasma levels of PAF in patients with sepsis, different severity of sepsis and patients with different outcomes were significantly positively correlated with the plasma level of Cor（P〈0. 01）. Conclusion：The levels of plasm