中文摘要：

目的研究乙型肝炎病毒（HBV）宫内感染的危险因素。方法采用巢式病例对照研究的方法，进行HBV宫内感染危险因素的logistic回归分析。结果HBV宫内感染危险因素的单因素分析显示在d=0．05水平上，孕妇DR3、婴儿DR3、母婴DR3同阳性、孕妇血清HBVDNA阳性、孕妇血清HBeAg阳性和胎盘感染在病例组和对照组差异均有统计学意义；是HBV宫内感染的危险因素，OR值（95％CJ）分别为4.71（1．62～13．66）、3．91（1．18～12．94）、5．96（1．14～31．15）、6．59（2．72～15．97）、4．53（1．93～10．64）和2．51（1．12～5．60）；在α入=0．05，α出=0．10水平上，进行HBV宫内感染的多因素logistic回归分析，孕妇DR3（OR=4．65，1．44～15．05）、孕妇血清HBVDNA（OR=6．56，2．65～16．23）被引入回归方程，为HBV宫内感染的危险因素，且两因素间未显示交互作用；其他因素的暴露率在病例组和对照组未见明显差别。随着孕妇血清HBVDNA含量的增加，其发生宫内感染的危险性呈现增高趋势（χ^2=16．74，P〈0.05）。结论HBV宫内感染的危险因素为孕妇HLA-DR3阳性和孕妇血清HBVDNA阳性，且两因素间未显示交互作用，HBV宫内感染率随孕妇血中HBVDNA含量增高呈增高趋势。

英文摘要：

Objective To study the risk factors of hepatitis B virus （HBV） intrauterine infection. Methods Risk factors of HBV intrauterine infection were analyzed by nested case control study. Results Data from univariate analysis revealed that risk factors of HBV intrauterine infection were positive results on HLA-DR3 （OR =4.71,1.62-13.66）,HBV DNA （OR - 6.59,2.72-15.97） and HBeAg （OR = 4.53, 1.93-10.64） in pregnant women,HLA-DR3 （OR 3.91,1.18-12.94） in newborn,HLA-DR3 （OR= 5.96,1.14-31.15） both in pregnant women and her newborns and HBV infection in placentas （OR = 2.51,1.12-5.60）. Results from Multivariate unconditional logistics regression analysis showed that the risk factors of HBV intrauterine infection were positive in both HLA-DR3（ OR = 4.65,1.44-15.05） and HBV DNA （OR = 6.56,2.65-16.23） in pregnant women. However, there was no interaction between the two factors. The exposure rate of other factors did not reveal the difference in the two groups. With the increase of HBV DNA in pregnant women, the risk of HBV intrauterine infection was rising （χ^2= 16.74, P〈 0.05）. Conclusion Risk factors of HBV intrauterine infection were HLA-DR3 positive and HBV DNA positive in pregnant women but there was no interaction between the two factors. The risk of HBV intrauterine infection was increased along with the increase of HBV DNA in pregnant women.