中文摘要：

目的了解Toll样受体（TLR3）在正常和HBsAg阳性孕妇胎盘各层细胞中的分布，探索TLR3在胎盘HBV感染中的作用。方法免疫组织化学（SABC）法检测19例正常孕妇胎盘和102例HBsAg阳性孕妇胎盘组织中TLR3和HBsAg。结果TLR3在正常孕妇胎盘阳性率100．00％（19／19），HBsAg阳性孕妇胎盘阳性率74．51％（76／102）；102例HBsAg阳性孕妇胎盘发生乙型肝炎病毒（HBV）感染为33例；TLR3在正常孕妇胎盘和HBsAg阳性孕妇胎盘上的分布差异有统计学意义（X^2=6．17，P=0．012）；TLR3与胎盘HBV感染的关系差异有统计学意义（X^2=13．581，P=0．0001）。结论TLR3可能是HBsAg阳性孕妇胎盘发生HBV感染的一个保护因素（OR=0．180．95％CI=0．069-0．469）。

英文摘要：

Objective To investigate the presence and distribution of toll-like receptors 3（TLR3） in term human placenta from normal and HBsAg-positive pregnant women and to explore the role of TLR3 in placenta HBV infection. Methods TLR3 and HBsAg in placentas of 19 normal and 102 HBsAg-positive pregnant women were detected by immunohistochemistry SABC. Results The positive rate of TLR3 in normal pregnant women was 100.00 % （19/19） and 74.51% （76/102） in HBsAg-positive pregnant women;33 of 102 placentas were infected by HBsAg; There was statistical difference in distribution of TLR3 between placentas of normal and HBsAg-positive pregnant women（X^2 = 6.17, P = 0. 012） ; the relationship between TLR3 and HBV infection was significant（X^2 = 13. 581, P 〈 0. 000 1 ）. Conclusion TLR3 is a protect factor of HBV infection in placentas（ OR = 0. 180, 0. 069-0. 469）.