中文摘要：

目的：研究高交感活性诱发大鼠心肌损伤的氧化应激受体调控机制。方法：Sprague-Dawley （ SD）大鼠随机分为对照组、模型组、普萘洛尔（Pro）组、哌唑嗪（Praz）组、普萘洛尔＋哌唑嗪（Pro＋Praz）组、维生素E （VE）组及普萘洛尔＋哌唑嗪＋维生素E （Pro＋Praz＋VE）组，除对照组外其余各组均腹腔注射去甲肾上腺素（ NE）复制高交感活性引起的心肌损伤模型，同时灌胃给予相应药物，连续给药16 d，期间监测各组动物体重的变化。16 d后进行心室重构指标（心指数和羟脯氨酸含量）、病理组织学检查、氧化／抗氧化指标（ MDA、SOD、CAT、GSH-Px和T-AOC）和能量代谢指标（ Na^＋-K^＋ATPase和Ca2^＋-Mg^2＋ATPase）分析。结果：从第9天开始，模型组动物体重与对照组的比较差异有统计学意义（P＜0．05），心指数和左心室肥厚明显增加，氧化／抗氧化和能量代谢障碍；Pro、Praz、Pro＋Praz和VE各组均出现不同程度的动物体重、心指数、左心室肥厚和氧化／抗氧化失衡的改善；Pro、Praz和Pro＋Praz能明显升高左心室Na^＋-K^＋ATPase和Ca^2＋-Mg^2＋ATPase的活性，Pro＋Praz作用最明显（ P＜0．05）。结论：肾上腺素受体依赖是高交感活性诱导心肌氧化应激损伤的重要途径。

英文摘要：

AIM：To investigate the dependence of the adrenoceptor regulation on oxidative stress in the rats with cardiac injury induced by high sympathetic activity .METHODS： Healthy SD rats were randomly divided into 7 groups：control, model, propranolol （Pro）, prazosin （Praz）, Pro＋Praz, vitamin E （VE） and Pro＋Praz＋VE.The rats were intraperitoneally injected with norepinephrine （ NE） for continuous 16 d to reproduce cardiac injury , and treated with the respective drugs .During the experimental process , the body weight was recorded .At the end of the experiments , the following parameters were measured：the ventricular remodeling indexes （ cardiac index and hydroxyproline of the left ventricle）, histopathologic examination , oxidative/antioxidative indexes [MDA, SOD, catalase （CAT）, GSH-Px and total an-tioxidant capacity （T-AOC）], and energy metabolism （Na^＋-K^＋ATPase and Ca^2＋-Mg^2＋ATPase）.RESULTS： The in-crease of body weight in model group was significantly slower than that in control group after 9 d of treatment （P〈0.05）. The cardiac index and left ventricular hypertrophy were significantly increased .Oxidation/antioxidation and energy metabo-lism were disturbed.In Pro, Praz, Pro＋Praz and VE groups, the body weight, cardiac index, left ventricular fibrosis and oxidative/antioxidative dysfunction were ameliorated .Pro, Praz and Pro ＋Praz increased the activity of Na ^＋-K^＋ATPase and Ca^2＋-Mg^2＋ATPase.Treatment with Pro＋Praz showed the best result in all of the indexes （P〈0.05）.CONCLU-SION：The dependence of adrenoceptor regulation plays an important role in the formation of oxidative stress in the process＆amp;nbsp;of rat cardiac injury induced by high sympathetic activity .