中文摘要：

为探讨异常黑胆质成熟剂对异常黑胆质型肝癌病证大鼠模型肝脏形态学的影响，按照维吾尔医模型建立标准，采用干寒环境、千寒饲料和异常物理刺激等多重因素复合作用，建立维医异常黑胆质证载体动物模型。在此基础上，通过饮用灭菌食用水配制浓度为0．1 mg／mL二乙基亚硝胺（DEN）溶液建立异常黑胆质型肝癌病证载体大鼠模型。并用大、中、小不同剂量（6．0、3．0、1．5 g／kg）异常黑胆质成熟剂进行全程干预，共分为病证模型组、小剂量组、中剂量组、大剂量组、正常对照组、肝癌对照组6组，每组24只。干预20周时处死大鼠，对肝脏的病理变化和超微结构进行观察。研究发现，20周时。低剂量组与病证模型组相比，形态无明显差异，高剂量组和中剂量组与病证模型组相比，具有肝细胞结缔组织增生减少、间质炎性细胞浸润程度明显减轻、肝细胞水肿程度减轻等病理表现及肝细胞内细胞器分布不均匀、肝糖原和线粒体逐渐减少等超微结构明显变化。研究表明，异常黑胆质成熟剂对异常黑胆质型肝癌病证模型的肝脏组织形态改变有一定的保护和修复作用。

英文摘要：

To find how the abnoinal savda munziq affects the hepatocarcinoma cell morphology of abnormal savda rat, rats were under the stimulations of dry cold environment and dry cold feed and abnormal physical stimulation to establish a model with the abnormal savda according to Uyghur medicine theory. They were raised by sterilized edible water with 0.1 mg/mL of diethylnitrosamine （DEN） solution to establish the hepatocareinoma model. The rats were treated with high and middle and low doses （6.0, 3.0, 1.5 g/kg） in three groups during the whole period. There were the abnormal savda and HCC model group, low dosage group, middle dosage group, high dosage group, normal control group, and HCC control group, with 24 rats in each group. The animals wereanesthetized and killed at the 20th week, then HE staining and observation of morphological characteristics of livers were performed. The results revealed the followings： Albeit no significant differences were found between low dosage group and model groups in morphology, compared with the model groups in high dosage or middle dosage, hyperplasia of connective tissue decreases and the degree of interstitial infiltration of inflammatory cells reduced significantly, cell edema alleviated, reductions of organelle nonuniform, glycogen and mitochondria were significant in the model group. Our findings indicate that the abnormal savda mnnziq can depress the transformation of hepatocyte to hepatocellular carcinoma in the process of chimeric rats.